| Author | Parcial, André Luiz N. | |
| Author | Salomão, Natália Gedeão | |
| Author | Portari, Elyzabeth Avvad | |
| Author | Arruda, Laíza Vianna | |
| Author | Carvalho, Jorge José de | |
| Author | Guedes, Herbert Leonel de Matos | |
| Author | Conde, Thayana Camara | |
| Author | Moreira, Maria Elizabeth | |
| Author | Batista, Marcelo Meuser | |
| Author | Paes, Marciano Viana | |
| Author | Rabelo, Kíssila | |
| Author | Gomes-Silva, Adriano | |
| Access date | 2022-11-16T13:19:06Z | |
| Available date | 2022-11-16T13:19:06Z | |
| Document date | 2022 | |
| Citation | PARCIAL, André Luiz N. et al. SARS-CoV-2 is persistent in placenta and causes macroscopic, histopathological, and ultrastructural changes. Viruses, v. 14, n. 9, p. 1-14, 2022. | en_US |
| ISSN | 1999-4915 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55630 | |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | |
| Subject in Portuguese | COVID-19 | |
| Subject in Portuguese | Mulheres grávidas | |
| Subject in Portuguese | Partículas virais | |
| Subject in Portuguese | Patogênese | |
| Subject in Portuguese | Inflamação | |
| Title | SARS-CoV-2 Is Persistent in Placenta and Causes Macroscopic, Histopathological, and Ultrastructural Changes | en_US |
| Type | Article | |
| DOI | 10.3390/v14091885 | |
| Abstract | SARS-CoV-2 is a virus that belongs to the Betacoronavirus genus of the Coronaviridae family. Other coronaviruses, such as SARS-CoV and MERS-CoV, were associated with complications in pregnant women. Therefore, this study aimed to report the clinical history of five pregnant women infected with SARS-CoV-2 (four symptomatic and one asymptomatic who gave birth to a stillborn child) during the COVID-19 pandemic. They gave birth between August 2020 to January 2021, a period in which there was still no vaccination for COVID-19 in Brazil. In addition, their placental alterations were later investigated, focusing on macroscopic, histopathological, and ultrastructural aspects compared to a prepandemic sample. Three of five placentas presented SARS-CoV-2 RNA detected by RT-PCRq at least two to twenty weeks after primary pregnancy infection symptoms, and SARS-CoV-2 spike protein was detected in all placentas by immunoperoxidase assay. The macroscopic evaluation of the placentas presented congested vascular trunks, massive deposition of fibrin, areas of infarctions, and calcifications. Histopathological analysis showed fibrin deposition, inflammatory infiltrate, necrosis, and blood vessel thrombosis. Ultrastructural aspects of the infected placentas showed a similar pattern of alterations between the samples, with predominant characteristics of apoptosis and detection of virus-like particles. These findings contribute to a better understanding of the consequences of SARS-CoV-2 infection in placental tissue, vertical transmission. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisa Médica. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisa Médica. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Anatomia Patológica. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisa Médica. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisa Médica. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Laranjeiras Health House. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Anatomia Patológica. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Anatomia Patológica. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisa Médica. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisa Médica. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | COVID-19 | en_US |
| Subject | Inflammation | en_US |
| Subject | Pathogenesis | en_US |
| Subject | Pregnant women | en_US |
| Subject | Viral particles | en_US |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
