| Author | Batista, Fabiani de Morais | |
| Author | Puga, Marco Antonio Moreira | |
| Author | Silva, Patricia Vieira da | |
| Author | Oliveira, Roberto | |
| Author | Santos, Paulo Cesar Pereira dos | |
| Author | Silva, Bruna Oliveira da | |
| Author | Tatara, Mariana Bento | |
| Author | Tsuha, Daniel Henrique | |
| Author | Pires, Maria Aparecida dos Santos | |
| Author | Gonçalves, Crhistinne Cavalheiro Maymone | |
| Author | Silva, Rômulo Pessoa E. | |
| Author | Ferreira, Nathália Tavares | |
| Author | Albuquerque, Amanda Pinheiro de Barros | |
| Author | Duarte, Giselle da Silva | |
| Author | Consolaro, Márcia Edilaine Lopes | |
| Author | Negrão, Fabio Juliano | |
| Author | Ferrari, Idalina Cristina | |
| Author | Cavalcanti, Luciano Pamplona de Goes | |
| Author | Trinta, Karen Soares | |
| Author | Ribeiro, Guilherme S. | |
| Author | Rêgo, Moacyr Jesus Barreto de Melo | |
| Author | Boyton, Rosemary J. | |
| Author | Siqueira, André Machado | |
| Author | Altmann, Daniel M. | |
| Author | Croda, Julio | |
| Access date | 2022-11-16T19:40:48Z | |
| Available date | 2022-11-16T19:40:48Z | |
| Document date | 2022 | |
| Citation | BATISTA, Fabiani de Morais et al. Serum biomarkers associated with SARS-CoV-2 severity. Scientific Reports, v. 12, n. 1, p. 1-9, 2022. | en_US |
| ISSN | 2045-2322 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55665 | |
| Language | eng | en_US |
| Publisher | Nature | en_US |
| Rights | open access | en_US |
| Title | Serum biomarkers associated with SARS-CoV-2 severity | en_US |
| Type | Article | en_US |
| DOI | 10.1038/s41598-022-20062-5 | |
| Abstract | Immunity with SARS-CoV-2 infection during the acute phase is not sufficiently well understood to differentiate mild from severe cases and identify prognostic markers. We evaluated the immune response profile using a total of 71 biomarkers in sera from patients with SARS-CoV-2 infection, confirmed by RT-PCR and controls. We correlated biological marker levels with negative control (C) asymptomatic (A), nonhospitalized (mild cases-M), and hospitalized (severe cases-S) groups. Among angiogenesis markers, we identified biomarkers that were more frequently elevated in severe cases when compared to the other groups (C, A, and M). Among cardiovascular diseases, there were biomarkers with differences between the groups, with D-dimer, GDF-15, and sICAM-1 higher in the S group. The levels of the biomarkers Myoglobin and P-Selectin were lower among patients in group M compared to those in groups S and A. Important differences in cytokines and chemokines according to the clinical course were identified. Severe cases presented altered levels when compared to group C. This study helps to characterize biological markers related to angiogenesis, growth factors, heart disease, and cytokine/chemokine production in individuals infected with SARS-CoV-2, offering prognostic signatures and a basis for understanding the biological factors in disease severity. | en_US |
| Affilliation | Federal University of Mato Grosso do Sul. School of Medicine. Campo Grande, MS, Brazil. | en_US |
| Affilliation | Federal University of Mato Grosso do Sul. School of Medicine. Campo Grande, MS, Brazil. | en_US |
| Affilliation | Federal University of Mato Grosso do Sul. School of Medicine. Campo Grande, MS, Brazil. | en_US |
| Affilliation | State University of Mato Grosso do Sul. Associated Prof. Nursing Course. Dourados, MS, Brazil. | en_US |
| Affilliation | Federal University of Mato Grosso do Sul. School of Medicine. Campo Grande, MS, Brazil. | en_US |
| Affilliation | Federal University of Grande Dourados. Faculty of Health Science. Laboratory of Research in Health Science. Dourados, MS, Brazil. | en_US |
| Affilliation | Federal University of Grande Dourados. Faculty of Health Science. Laboratory of Research in Health Science. Dourados, MS, Brazil. | en_US |
| Affilliation | Center for Strategic Information in Health Surveillance. State Health Department of Mato Grosso do Sul. Campo Grande, MS, Brazil. | en_US |
| Affilliation | Federal University of Grande Dourados. Faculty of Health Sciences. Dourados, MS, Brazil / Federal University of Grande Dourados. Universitary Hospital. Dourados, MS, Brazil. | en_US |
| Affilliation | Federal University of Mato Grosso do Sul. School of Medicine. Campo Grande, MS, Brazil. | en_US |
| Affilliation | Federal University of Pernambuco. Recife, PE, Brazil. | en_US |
| Affilliation | Federal University of Pernambuco. Recife, PE, Brazil. | en_US |
| Affilliation | Federal University of Pernambuco. Recife, PE, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica de Doença Febril Aguda. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | State University of Maringá. Postgraduate Program in Biosciences and Pathophysiology. Maringá, PR, Brazil / State University of Maringá. Regional University Hospital of Maringá. Maringá, PR, Brazil. | en_US |
| Affilliation | Federal University of Grande Dourados. Faculty of Health Sciences. Dourados, MS, Brazil / Federal University of Grande Dourados. Universitary Hospital. Dourados, MS, Brazil. | en_US |
| Affilliation | Federal University of Grande Dourados. Faculty of Health Sciences. Dourados, MS, Brazil. | en_US |
| Affilliation | Federal University of Ceará. Postgraduate Program in Public Health. Fortaleza, CE, Brazil / Christus University Center. School of Medicine. Fortaleza, CE, Brazil / Federal University of Ceará. Postgraduate Program in Pathology. Fortaleza, CE, Brazil . | en_US |
| Affilliation | Fundação Oswaldo Cruz. Bio-manguinhos. Laboratório de Tecnologia Diagnóstica. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | en_US |
| Affilliation | Federal University of Pernambuco. Recife, PE, Brazil. | en_US |
| Affilliation | Imperial College London. Department of Infectious Disease. London, UK / Royal Brompton. Lung Division. London, UK / Harefield Hospitals. London, UK. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Imperial College London. Department of Immunology and Inflammation. London, UK. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil / Federal University of Mato Grosso do Sul. School of Medicine. Campo Grande, MS, Brazil. | en_US |
| Subject | COVID-19 | en_US |
| Subject | SARS-CoV-2 severity | en_US |
| Subject | RT-PCR | en_US |
| Subject | Serum biomarkers | en_US |
