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| Autor | Almeida-Paes, Rodrigo | |
| Autor | Almeida, Marcos de Abreu | |
| Autor | Macedo, Priscila Marques de | |
| Autor | Caceres, Diego H. | |
| Autor | Zancopé-Oliveira, Rosely Maria | |
| Fecha de acceso | 2022-11-17T17:38:02Z | |
| Fecha de disponibilización | 2022-11-17T17:38:02Z | |
| Fecha de publicación | 2022 | |
| Referencia | ALMEIDA-PAES, Rodrigo et al. Performance of Two Commercial Assays for the Detection of Serum Aspergillus Galactomannan in Non-Neutropenic Patients. Journal of fungi, v. 8, n. 7, p. 1-11, 2022. | en_US |
| ISSN | 2309-608X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55681 | |
| Idioma | eng | en_US |
| Editor | MDPI | en_US |
| Derechos de autor | open access | en_US |
| Título | Performance of Two Commercial Assays for the Detection of Serum Aspergillus Galactomannan in Non-Neutropenic Patients | en_US |
| Tipo del documento | Article | en_US |
| DOI | 10.3390/jof8070741 | |
| Resumen en Inglés | Besides the relevance of aspergillosis in neutropenic patients, this mycosis has gained significance among non-neutropenic patients in last years. The detection of Aspergillus galactomannan has been used for aspergillosis diagnosis and follow-up in neutropenic patients. This study evaluated the applicability of two commercial tests for galactomannan detection in non-neutropenic patients with different clinical forms of aspergillosis. Serum samples from patients with chronic pulmonary aspergillosis, aspergilloma, invasive aspergillosis, and COVID-19 associated pulmonary aspergillosis were evaluated using the IMMY sōna AGM lateral flow assay and the Bio-Rad Platelia sandwich ELISA. Serum specimens from patients with tuberculosis, histoplasmosis, paracoccidioidomycosis, and from healthy individuals were used as controls. The Bio-Rad Platelia sandwich ELISA presented greater sensitivity, whereas the IMMY sōna AGM lateral flow assay presented greater specificity. The accuracies of the tests were similar, as demonstrated by a receiver operator characteristic analysis. Moreover, the best cut-off values determined by this analysis were closer to that recommended by both manufacturers for neutropenic patients. The galactomannan indexes determined by different methodologies were strongly related, and a substantial agreement was observed between results. Both tests can be used in non-neutropenic patients with the cut-off values defined by the manufacturers. Histoplasma cross-reactions may occur in areas where histoplasmosis is endemic. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliación | Immuno-Mycologics. Norman, OK, USA / Center of Expertise in Mycology Radboudumc/CWZ. Nijmegen, The Netherlands / Universidad del Rosario. School of Medicine and Health Sciences. Studies in Translational Microbiology and Emerging Diseases Research Group. Bogota, Colombia. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Palavras clave en Inglês | Aspergillus antigen | en_US |
| Palavras clave en Inglês | ELISA | en_US |
| Palavras clave en Inglês | Diagnosis | en_US |
| Palavras clave en Inglês | Lateral flow | en_US |
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INI - Artigos de Periódicos [3646]