| Author | Almeida, Alisson Andrade | |
| Author | Cota, Betania Barros | |
| Author | Rodrigues, Laís A. | |
| Author | Dutra, Luana L. | |
| Author | Kohlhoff, Markus | |
| Author | Bressan, Gustavo C. | |
| Author | Brandão, Geraldo Celio | |
| Author | Leite, João P. V. | |
| Access date | 2022-11-21T17:58:26Z | |
| Available date | 2022-11-21T17:58:26Z | |
| Document date | 2022 | |
| Citation | ALMEIDA, Alisson Andrade et al. Withalutin, a new cytotoxic withanolide from Athenaea velutina (Sendtn.) D'Arcy. Natural Product Research, v. 2022, p. 1-8, 2022. | en_US |
| ISSN | 1478-6419 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55742 | |
| Language | eng | en_US |
| Publisher | Taylor & Francis Health Sciences | en_US |
| Rights | restricted access | |
| Title | Withalutin, a new cytotoxic withanolide from Athenaea velutina (Sendtn.) D'Arcy | en_US |
| Type | Article | |
| DOI | 10.1080/14786419.2022.2039135 | |
| Abstract | Bioassay-guided fractionation of dichloromethane extract from Athenaea velutina leaves led to the isolation of three withanolides, all being reported for the first time in this species. They were identified as withacnistin (1), withacnistin acetate (2) and a new withanolide, designated as withalutin (3). The structures were established by spectral data analysis, including MS, 1D and 2D NMR. In addition, in silico ADMET studies were employed to understand the pharmacokinetic properties of these withanolides. The withanolides isolated from A. velutina reduced cancer cell viability with IC50 values ranging from 1.52 to 5.39 µM. In silico prediction revealed that withanolides have good gastrointestinal absorption or oral bioavailability properties; and are not likely to be mutagenic or hepatotoxic. These findings revealed that A. velutina is an important source of cytotoxic withanolides. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Ouro Preto. Escola de Farmácia. Ouro Preto, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Subject | Athenaea velutina | en_US |
| Subject | Cytotoxic activities | en_US |
| Subject | In silico ADMET analysis | en_US |
| Subject | Withalutin | en_US |
| Subject | Withanolides | en_US |
| Embargo date | 2097 | |
