| Author | Freitas, Natália Erdens Maron | |
| Author | Habib, Fernanda Lopes | |
| Author | Santos, Emily Ferreira | |
| Author | Silva, Ângelo Antônio Oliveira | |
| Author | Fontes, Natália Dantas | |
| Author | Leony, Leonardo Maia | |
| Author | Sampaio, Daniel Dias | |
| Author | Almeida, Marcio Cerqueira de | |
| Author | Torres, Filipe Dantas | |
| Author | Santos, Fred Luciano Neves | |
| Access date | 2022-11-23T17:42:37Z | |
| Available date | 2022-11-23T17:42:37Z | |
| Document date | 2022 | |
| Citation | FREITAS, Natália Erdens Maron et al. Technological advances in the serological diagnosis of Chagas disease in dogs and cats: a systematic review. Parasites & Vectors. v. 15, n. 343, p. 1-20, 2022. | en_US |
| ISSN | 1756-3305 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55769 | |
| Language | eng | en_US |
| Publisher | BMC | en_US |
| Rights | open access | |
| Subject in Portuguese | Trypanosoma cruzi | en_US |
| Subject in Portuguese | Cães | en_US |
| Subject in Portuguese | Gatos | en_US |
| Subject in Portuguese | Diagnose | en_US |
| Subject in Portuguese | Sorologia | en_US |
| Subject in Portuguese | Epidemiologia | en_US |
| Title | Technological advances in the serological diagnosis of Chagas disease in dogs and cats: a systematic review | en_US |
| Type | Article | |
| DOI | 10.1186/s13071-022-05476-4 | |
| Abstract | Background: Chagas disease (CD) is caused by Trypanosoma cruzi, which is transmitted mainly through the feces/
urine of infected triatomine bugs. The acute phase lasts 2–3 months and is characterized by high parasitemia and
nonspecific symptoms, whereas the lifelong chronic phase features symptoms affecting the heart and/or digestive
tract occurring in 30–40% of infected individuals. As in humans, cardiac abnormalities are observed in T. cruzi-infected
dogs and cats. We reviewed the technological advances in the serological diagnosis of CD in dogs and cats.
Methods: A review of the published literature during the last 54 years (1968–2022) on the epidemiology, clinical
features, diagnosis, treatment and prevention of CD in dogs and cats was conducted.
Results: Using predefined eligibility criteria for a search of the published literature, we retrieved and screened 436
publications. Of these, 84 original studies were considered for inclusion in this review. Dogs and cats are considered
as sentinels, potentially indicating an active T. cruzi transmission and thus the risk for human infection. Although dogs
and cats are reputed to be important for maintaining the T. cruzi domestic transmission cycle, there are no commercial
tests to detect past or active infections in these animals. Most published research on CD in dogs and cats have
used in-house serological tests prepared with native and/or full-length recombinant antigens, resulting in variable
diagnostic performance. In recent years, chimeric antigens have been used to improve the diagnosis of chronic CD in
humans with encouraging results. Some of them have high performance values (> 95%) and extremely low crossreactivity
rates for Leishmania spp., especially the antigens IBMP-8.1 to IBMP-8.4. The diagnostic performance of IBMP
antigens was also investigated in dogs, showing high diagnostic performance with negligible cross-reactivity with
anti-Leishmania infantum antibodies.
Conclusions: The development of a commercial immunodiagnostic tool to identify past or active T. cruzi infections
in dogs and cats is urgently needed. The use of chimeric recombinant T. cruzi antigens may help to fill this gap and is
discussed in this review. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | en_US |
| Affilliation | Prefeitura Municipal de Tremedal. Secretaria Municipal de Saúde. Estratégia Saúde da Família Brasil. Tremedal, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunoparasitologia. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa Tradicional Integrado na Doença de Chagas da Fiocruz. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Trypanosoma cruzi | en_US |
| Subject | Dogs | en_US |
| Subject | Cats | en_US |
| Subject | Diagnosis | en_US |
| Subject | Serology | en_US |
| Subject | Epidemiology | en_US |
