Author | Fuller, Trevon | |
Author | Kein, Tara | |
Author | Cortado, Ruth | |
Author | Teixeira, Maria de Lourdes Benamor | |
Author | Gouvêa, Maria Isabel Fragoso da Silveira | |
Author | Moreira, Christianne | |
Author | Cruz, Maria Leticia Santos | |
Author | Pilotto, José Henrique | |
Author | Gomes, Ivete | |
Author | Santos, Breno | |
Author | Rocha, Tauí | |
Author | Sony, Priya R. | |
Author | João, Esau | |
Author | Shin-Sim, Myung | |
Author | Bryson, Yvonne | |
Author | Nielsen-Saines, Karin | |
Access date | 2022-11-25T19:00:57Z | |
Available date | 2022-11-25T19:00:57Z | |
Document date | 2022 | |
Citation | FULLER, Trevon et al. Sustained Virologic Suppression Reduces HIV-1 DNA Proviral Levels and HIV Antibodies in Perinatally HIV-Infected Children Followed from Birth. Viruses, v. 14, 2350, p. 1-13, Oct. 2022. | en_US |
ISSN | 1999-4915 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/55805 | |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | |
Subject in Portuguese | Tratamento precoce do HIV | en_US |
Subject in Portuguese | Carga do reservatório viral | en_US |
Subject in Portuguese | PCR digital de gota de DNA de HIV | en_US |
Subject in Portuguese | Cinética da carga viral | en_US |
Subject in Portuguese | Infecção perinatal por HIV | en_US |
Title | Sustained Virologic Suppression Reduces HIV-1 DNA Proviral Levels and HIV Antibodies in Perinatally HIV-Infected Children Followed from Birth | en_US |
Type | Article | |
DOI | 10.3390/v14112350 | |
Abstract | The extent to which perinatally HIV-infected children, following cART initiation, develop a
low proviral reservoir burden over time, as measured by HIV DNA droplet-digital polymerase chain reaction (ddPCR) and the effect on HIV antibody is not well characterized. We measured proviral HIV DNA and plasma RNA virus load (VL) in 37 perinatally HIV-infected children at 6 months of age who initiated stable cART. At 6–11 years of age, HIV proviral DNA, HIV VL (RNA), and HIV antibody by Western Blot (WB) were assessed. CART was initiated before 6 months of age in 13 children and after 6 months in 24. At school age, the HIV DNA levels did not differ by the timing of cART, and the HIV DNA levels were lower in children with negative/indeterminate WB (p = 0.0256). Children with undetectable HIV RNA VL > 50% of the time since cART initiation had lower median DNA VL than children with undetectable VL < 50% of the time (p = 0.07). Long-term viral suppression in perinatally HIV-infected children is associated with a decrease in HIV antibodies and reduced HIV reservoirs. | en_US |
Affilliation | Institute of the Environment & Sustainability, University of California Los Angeles. Los Angeles, CA, USA / Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Pediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles. CA, USA. | en_US |
Affilliation | Pediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles. CA, USA. | en_US |
Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil. | en_US |
Affilliation | Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brasil. | en_US |
Affilliation | Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brasil. | en_US |
Affilliation | Cedars Sinai Medical Center, Los Angeles. CA, USA. | en_US |
Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil | en_US |
Affilliation | Pediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA, USA. | en_US |
Affilliation | Pediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA, USA. | en_US |
Affilliation | Pediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA, USA. | en_US |
Subject | Early HIV treatment | en_US |
Subject | Viral reservoir burden | en_US |
Subject | HIV DNA droplet digital PCR | en_US |
Subject | Viral load kinetics | en_US |
Subject | Perinatal HIV infection | en_US |