| Author | Trindade, Joana D’Arc S. | |
| Author | Lima, Célio Geraldo Freire de | |
| Author | Cõrte-Real, Suzana | |
| Author | Decote-Ricardo, Debora | |
| Author | LIma, Marco Edilson Freire de | |
| Access date | 2022-12-03T11:53:09Z | |
| Available date | 2022-12-03T11:53:09Z | |
| Document date | 2021 | |
| Citation | TRINDADE, Joana D`Arc S. et al. Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action. Plos One, v. 16, n.10, e0258292, p. 1-15, Oct. 2021. | en_US |
| ISSN | 1932-6203 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/55875 | |
| Language | eng | en_US |
| Publisher | Public Library of Science | en_US |
| Rights | open access | |
| Subject in Portuguese | Doença de Chagas | en_US |
| Subject in Portuguese | Reaproveitamento de medicamentos | en_US |
| Subject in Portuguese | In vitro avaliação de nimesulida | en_US |
| Subject in Portuguese | Trypanosoma cruzi | en_US |
| Subject in Portuguese | Insights sobre seus mecanismos de ação | en_US |
| Title | Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action | en_US |
| Type | Article | |
| DOI | 10.1371/journal. pone.0258292 | |
| Abstract | Chagas disease is a neglected illness caused by Trypanosoma cruzi and its treatment is done only with two drugs, nifurtimox and benznidazole. However, both drugs are ineffective in the chronic phase, in addition to causing serious side effects. This context of therapeutic limitation justifies the continuous research for alternative drugs. Here, we study the in vitro trypanocidal effects of the non-steroidal anti-inflammatory drug nimesulide, a molecule that has in its chemical structure a toxicophoric nitroaromatic group (NO2). The set of results obtained in this work highlights the potential for repurposing nimesulide in the treatment of this disease that affects millions of people around the world. | en_US |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Química. Departamento de Química Orgãnica. Rio de janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Departamento de Microbiologia e Imunologia Veterinária. Seropédica, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Química. Departamento de Química Orgãnica. Rio de janeiro, RJ, Brasil. | en_US |
| Subject | Drug repurposing | en_US |
| Subject | Chagas disease | en_US |
| Subject | In vitro assessment of nimesulide | en_US |
| Subject | Trypanosoma cruzi | en_US |
| Subject | Insights | en_US |
| Subject | Its mechanisms of action | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
