Author | Wu, Wanqing | |
Author | Ding, Ding | |
Author | Zhao, Qianhua | |
Author | Xiao, Zhenxu | |
Author | Luo, Jianfeng | |
Author | Ganguli, Mary | |
Author | Hughes, Tiffany F | |
Author | Jacobsen, Erin | |
Author | Haan, Mary N | |
Author | Dang, Kristine van | |
Author | Costa, Maria Fernanda Furtado Lima | |
Author | Blay, Sergio Luis | |
Author | Costa, Erico de Castro | |
Author | Ng, Tze Pin | |
Author | Gwee, Xinyi | |
Author | Gao, Qi | |
Author | Gureje, Oye | |
Author | Ojagbemi, Akin | |
Author | Bello, Toyin | |
Author | Shahar, Suzana | |
Author | Ludin, Arimi Fitri Mat | |
Author | Rivan, Nurul Fatin Malek | |
Author | Scarmeas, Nikolaos | |
Author | Anastasiou, Costas A | |
Author | Yannakoulia, Mary | |
Author | Brodaty, Henry | |
Author | Crawford, John D | |
Author | Lipton, Richard B | |
Author | Derby, Carol A | |
Author | Katz, Mindy J | |
Author | Lipnicki, Darren M | |
Author | Sachdev, Perminder S | |
Access date | 2022-12-05T15:26:18Z | |
Available date | 2022-12-05T15:26:18Z | |
Document date | 2022 | |
Citation | WU, W et al. Dose-response relationship between late-life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium. Alzheimers Dement, 2022, 10.1002/alz.12628, 2022. doi: 10.1002/alz.12628. | en_US |
ISSN | 1552-5260 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/55892 | |
Language | eng | en_US |
Publisher | John Wiley & Sons, Ltd | en_US |
Rights | restricted access | en_US |
Title | Dose-response relationship between late-life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium | en_US |
Type | Article | en_US |
Abstract | Introduction: Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear.
Methods: We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose-response relationship between late-life physical activity and incident dementia among older adults.
Results: Using no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose-response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)-hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET-hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET-hours/week).
Discussion: This cross-national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET-hours of energy per week may reduce dementia risk. | en_US |
Affilliation | Institute of Neurology. National Clinical Research Center for Aging and Medicine. National Center for Neurological Disorders. Huashan Hospital. Fudan University. Shanghai, China. | en_US |
Affilliation | Institute of Neurology. National Clinical Research Center for Aging and Medicine. National Center for Neurological Disorders. Huashan Hospital. Fudan University. Shanghai, China. | en_US |
Affilliation | Institute of Neurology. National Clinical Research Center for Aging and Medicine. National Center for Neurological Disorders. Huashan Hospital. Fudan University. Shanghai, China | en_US |
Affilliation | Institute of Neurology. National Clinical Research Center for Aging and Medicine. National Center for Neurological Disorders. Huashan Hospital. Fudan University. Shanghai, China. | en_US |
Affilliation | Department of Biostatistics. School of Public Health. Fudan University. Shanghai, China. | en_US |
Affilliation | Department of Psychiatry. University of Pittsburgh. Pittsburgh, PA, USA. | en_US |
Affilliation | Department of Health Professions. Youngstown State University. Youngstown, OH, USA. | en_US |
Affilliation | Department of Psychiatry. University of Pittsburgh. Pittsburgh, PA, USA. | en_US |
Affilliation | Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California, USA. | en_US |
Affilliation | Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California, USA. | en_US |
Affilliation | Center for Studies in Public Health and Aging. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, Brazil. | en_US |
Affilliation | Department of Psychiatry. Federal University of Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
Affilliation | Center for Studies in Public Health and Aging. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, Brazil. | en_US |
Affilliation | Department of Psychological Medicine. National University of Singapore. Singapore, Singapore. | en_US |
Affilliation | Department of Psychological Medicine. National University of Singapore. Singapore, Singapore. | en_US |
Affilliation | National Public Health and Epidemiology Unit, National Centre for Infectious Diseases. Singapore, Singapore. | en_US |
Affilliation | Department of Psychiatry, University of Ibadan, Ibadan, Nigeria. | en_US |
Affilliation | Department of Psychiatry, University of Ibadan, Ibadan, Nigeria. | en_US |
Affilliation | Department of Psychiatry, University of Ibadan, Ibadan, Nigeria. | en_US |
Affilliation | Dietetic Program. Centre for Healthy Aging. University Kebangsaan Malaysia. Kuala Lumpur, Malaysia. | en_US |
Affilliation | Biomedical Science Program. Centre for Healthy Aging. University Kebangsaan Malaysia. Kuala Lumpur, Malaysia. | en_US |
Affilliation | Nutritional Sciences Program. Centre for Healthy Aging. University Kebangsaan Malaysia. Kuala Lumpur, Malaysia. | en_US |
Affilliation | Department of Neurology. Columbia University. New York, NY, USA. | en_US |
Affilliation | Department of Nutrition and Dietetics. Harokopio University. Athens, Greece. | en_US |
Affilliation | Department of Nutrition and Dietetics. Harokopio University. Athens, Greece. | en_US |
Affilliation | Centre for Healthy Brain Ageing. University of New South Wales. Sydney, Australia. | en_US |
Affilliation | Centre for Healthy Brain Ageing. University of New South Wales. Sydney, Australia. | en_US |
Affilliation | Department of Neurology. Albert Einstein College of Medicine. New York, NY, USA | en_US |
Affilliation | Department of Neurology. Albert Einstein College of Medicine. New York, NY, USA | en_US |
Affilliation | Department of Neurology. Albert Einstein College of Medicine. New York, NY, USA | en_US |
Affilliation | Centre for Healthy Brain Ageing. University of New South Wales. Sydney, Australia. | en_US |
Affilliation | Centre for Healthy Brain Ageing. University of New South Wales. Sydney, Australia. | en_US |
Subject | cohort | en_US |
Subject | dementia | en_US |
Subject | dose-response | en_US |
Subject | physical activity | en_US |
Subject | pooled analysis | en_US |
Subject | population-based | en_US |
Embargo date | 2096 | |