| Author | Pereira, Mariana Araújo | |
| Author | Sheikh, Virginia | |
| Author | Sereti, Irini | |
| Author | Duarte, Beatriz Barreto | |
| Author | Arriaga, María B. | |
| Author | Tibúrcio, Rafael | |
| Author | Vinhaes, Caian L. | |
| Author | Almeida, Manuella Pinto de | |
| Author | Wang, Jing | |
| Author | Rupert, Adam | |
| Author | Roby, Gregg | |
| Author | Shaffer, Douglas | |
| Author | Ananworanich, Jintanat | |
| Author | Phanuphak, Nittaya | |
| Author | Sawe, Fred | |
| Author | Andrade, Bruno B. | |
| Access date | 2022-12-16T14:02:00Z | |
| Available date | 2022-12-16T14:02:00Z | |
| Document date | 2022 | |
| Citation | PEREIRA, Mariana Araújo et al. Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: A multinational cohort study. eBioMedicine, v. 85, p. 1-12, 2022. | en_US |
| ISSN | 2352-3964 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56010 | |
| Sponsorship | Pesquisa Interna do Instituto Nacional de Alergia e Doenças Infecciosas/Institutos Nacionais de
Saúde (NIAID/NIH).
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). | en_US |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Tuberculose | en_US |
| Subject in Portuguese | Inflamação sistêmica | en_US |
| Subject in Portuguese | IRIS | en_US |
| Subject in Portuguese | HIV | en_US |
| Title | Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: a multinational cohort study | en_US |
| Type | Article | en_US |
| DOI | 10.1016/j.ebiom.2022.104309 | |
| Abstract | Background: After initiating antiretroviral therapy (ART), approximately 25% of people with HIV (PWH) may develop Immune Reconstitution Inflammatory Syndrome (IRIS), which is associated with increased morbidity and mortality. Several reports have demonstrated that low haemoglobin (Hb) levels are a risk factor for IRIS. To what extent the severity of anaemia contributes to the risk of IRIS and/or death is still insufficiently explored. Methods: We investigated both the presence and severity of anaemia in PWH in a multinational cohort of ART-naïve patients. A large panel of plasma biomarkers was measured pre-ART and patients were followed up for 6 months. IRIS or deaths during this period were considered as outcomes. We performed multidimensional analyses, logistic regression, and survival curves to delineate associations. Findings: Patients with severe anaemia (SA) presented a distinct systemic inflammatory profile, characterized by higher TNF, IL-6, and IL-27 levels. SA was independently associated with IRIS, with a higher risk of both early IRIS onset and death. Among IRIS patients, those with SA had a higher risk of mycobacterial IRIS. Interpretation: PWH with SA display a more pronounced inflammatory profile, with an elevated risk of developing IRIS earlier and a statistically significant higher risk of death. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Patologia Humana e Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | National Institutes of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USA. | en_US |
| Affilliation | National Institutes of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil / Universidade Salvador. Curso de Medicina. Salvador. BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Patologia Humana e Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Patologia Humana e Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Fundação Bahiana para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | en_US |
| Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Salvador. Curso de Medicina. Salvador. BA, Brasil. | en_US |
| Affilliation | Clinical Monitoring Research Program Directorate. Frederick National Laboratory for Cancer Research. Frederick, MD, USA. | en_US |
| Affilliation | National Institutes of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USA. | en_US |
| Affilliation | National Institutes of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, USA. | en_US |
| Affilliation | Kenya Medical Research Institute. Henry Jackson Foundation Medical Research International. Bethesda, MD, USA / Walter Reed Army Institute of Research/US Army Medical Research Directorate-Africa. Nairobi, Kenya. | en_US |
| Affilliation | Southeast Asia Research Collaboration with Hawaii. Henry M. Jackson Foundation for the Advancement of Military Medicine. United States Military HIV Research Program. Bethesda, MD, USA. | en_US |
| Affilliation | SEARCH. Institute of HIV Research and Innovation. Bangkok, Thailand. | en_US |
| Affilliation | Kenya Medical Research Institute. Henry Jackson Foundation Medical Research International. Bethesda, MD, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Patologia Humana e Experimental. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil / Universidade Salvador. Curso de Medicina. Salvador. BA, Brasil. | en_US |
| Subject | Tuberculosis | en_US |
| Subject | Systemic inflammation | en_US |
| Subject | IRIS | en_US |
| Subject | Death | en_US |
| Subject | HIV | en_US |
| DeCS | Tuberculose | en_US |
| DeCS | Iris | en_US |
| DeCS | Morte | en_US |
| DeCS | HIV | en_US |
