| Author | Bagno, Flávia Fonseca | |
| Author | Andrade, Luis Adan Flores | |
| Author | Sérgio, Sarah A R | |
| Author | Parise, Pierina Lorencini | |
| Author | Teixeira, Daniel Augusto de Toledo | |
| Author | Gazzinelli, Ricardo Tostes | |
| Author | Fernandes, Ana Paula Salles Moura | |
| Author | Teixeira, Santuza Maria Ribeiro | |
| Author | Granja, Fabiana | |
| Author | Módena, José Luiz Proença | |
| Author | Fonseca, Flavio Guimarães da | |
| Access date | 2022-12-22T11:23:26Z | |
| Available date | 2022-12-22T11:23:26Z | |
| Document date | 2022 | |
| Citation | BAGNO, Flávia Fonseca. Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine. Viruses, v. 14, n. 3, 510, 2022. doi: 10.3390/v14030510. | en_US |
| ISSN | 1999-4915 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56150 | |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Title | Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine | en_US |
| Type | Article | en_US |
| Abstract | Previous studies have indicated that antibody responses can be robustly induced after the vaccination in individuals previously infected by SARS-CoV-2. To evaluate anti-SARS-CoV-2 humoral responses in vaccinated individuals with or without a previous history of COVID-19, we compared levels of anti-SARS-CoV-2 antibodies in the sera from 21 vaccinees, including COVID-19-recovered or -naïve individuals in different times, before and after immunization with an inactivated COVID-19 vaccine. Anti-SARS-CoV-2-specific antibodies elicited after COVID-19 and/or immunization with an inactivated vaccine were measured by ELISA and Plaque Reduction Neutralizing assays. Antibody kinetics were consistently different between the two vaccine doses for naïve individuals, contrasting with the SARS-CoV-2-recovered subjects in which we observed no additional increase in antibody levels following the second dose. Sera from SARS-CoV2-naïve individuals had no detectable neutralizing activity against lineage B.1 SARS-CoV-2 or Gamma variant five months after the second vaccine dose. Contrarily, SARS-CoV-2-recovered subjects retained considerable neutralizing activity against both viruses. We conclude that a single inactivated SARS-CoV-2 vaccine dose may be sufficient to induce protective antibody responses in individuals with previous history of SARS-CoV-2 infection. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Laboratory of Emerging Viruses. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil. | en_US |
| Affilliation | Laboratory of Emerging Viruses. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Laboratory of Emerging Viruses. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil/Biodiversity Research Center. Federal University of Roraima. Boa Vista, RO, Brazil. | en_US |
| Affilliation | Laboratory of Emerging Viruses. Department of Genetics, Evolution, Microbiology and Immunology. University of Campinas. Campinas, SP, Brazil/Experimental Medicine Research Cluster. State University of Campinas. Campinas, SP, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil. | en_US |
| Subject | COVID-19 | en_US |
| Subject | CoronaVac | en_US |
| Subject | ELISA | en_US |
| Subject | PRNT | en_US |
| Subject | antibodies | en_US |
