| Author | Giovanetti, Marta | |
| Author | Pereira, Luiz Augusto | |
| Author | Adelino, Talita Émile Ribeiro | |
| Author | Fonseca, Vagner | |
| Author | Xavier, Joilson | |
| Author | Fabri, Allison de Araújo | |
| Author | Slavov, Svetoslav Nanev | |
| Author | Lemos, Poliana da Silva | |
| Author | Marques, William de Almeida | |
| Author | Kashima, Simone | |
| Author | Lourenço, José | |
| Author | Oliveira, Tulio de | |
| Author | Albuquerque, Carlos Frederico Campelo de | |
| Author | Freitas, Carla | |
| Author | Peterka, Cassio Roberto Leonel | |
| Author | Cunha, Rivaldo Venancio da | |
| Author | Mendonça, Ana Flávia | |
| Author | Silva, Vinícius Lemes da | |
| Author | Alcântara, Luiz Carlos Junior | |
| Access date | 2022-12-23T13:40:17Z | |
| Available date | 2022-12-23T13:40:17Z | |
| Document date | 2022 | |
| Citation | GIOVANETTI, Marta et al. A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil. Microbiology Spectrum, v. 10, n. 2, p. 1 - 6, Mar./Apr. 2022. | en_US |
| ISSN | 2165-0497 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56186 | |
| Language | eng | en_US |
| Publisher | American Society for Microbiology | en_US |
| Rights | open access | |
| Subject in Portuguese | Zika vírus | en_US |
| Subject in Portuguese | LInhagem asiática | en_US |
| Subject in Portuguese | Centro-Oeste brasileiro | en_US |
| Subject in Portuguese | Epidemiologia genômica | en_US |
| Title | A retrospective overview of Zika virus evolution in the Midwest of Brazil | en_US |
| Type | Article | |
| DOI | 10.1128/spectrum.00155-22 | |
| Abstract | Since the introduction of the Zika virus (ZIKV) into Brazil in 2015, its transmission
dynamics have been intensively studied in many parts of the country, although
much is still unknown about its circulation in the midwestern states. Here, using nanopore
technology, we obtained 23 novel partial and near-complete ZIKV genomes from
the state of Goiás, located in the Midwest of Brazil. Genomic, phylogenetic, and epidemiological
approaches were used to retrospectively explore the spatiotemporal evolution
of the ZIKV-Asian genotype in this region. As a likely consequence of a gradual
accumulation of herd immunity, epidemiological data revealed a decline in the number
of reported cases over 2018 to 2021. Phylogenetic reconstructions revealed that multiple
independent introductions of the Asian lineage have occurred in Goiás over time and
revealed a complex transmission dynamic between epidemic seasons. Together, our
results highlight the utility of genomic, epidemiological, and evolutionary methods to
understand mosquito-borne epidemics.
IMPORTANCE Despite the considerable morbidity and mortality of arboviral infections
in Brazil, such as Zika, chikungunya, dengue fever, and yellow fever, our understanding
of these outbreaks is hampered by the limited availability of genomic data to track and
control the epidemic. In this study, we provide a retrospective reconstruction of the
Zika virus transmission dynamics in the state of Goiás by analyzing genomic data from
areas in Midwest Brazil not covered by other previous studies. Our study provides an
understanding of how ZIKV initiates transmission in this region and reveals a complex
transmission dynamic between epidemic seasons. Together, our results highlight the
utility of genomic, epidemiological, and evolutionary methods to understand mosquitoborne
epidemics, revealing how this toolkit can be used to help policymakers prioritize
areas to be targeted, especially in the context of finite public health resources. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros. Goiânia, GO, Brasil. | en_US |
| Affilliation | Fundação Ezequiel Dias. Laboratório Central de Saúde Pública. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Organização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, DF, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brasil. | en_US |
| Affilliation | Coordenação Geral das Arboviroses, Secretaria de Vigilância em Saúde/Ministério da Saúde (CGARB/SVS-MS). Brasília, DF, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brasil. | en_US |
| Affilliation | Department of Zoology, Peter Medawar Building, University of Oxford, Oxford, UK. | en_US |
| Affilliation | School for Data Science and Computational Thinking, Faculty of Science and Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa. | en_US |
| Affilliation | Organização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, DF, Brasil. | en_US |
| Affilliation | Coordenação Geral de Laboratórios de Saúde Pública/Secretaria de Vigilância em Saúde, Ministério da Saúde (CGLAB/SVS-MS), Brasília, DF, Brasil. | en_US |
| Affilliation | Coordenação Geral das Arboviroses, Secretaria de Vigilância em Saúde/Ministério da Saúde (CGARB/SVS-MS), Brasília, DF.Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz, Bio-Manguinhos, Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros, Goiânia, GO, Brasil. | en_US |
| Affilliation | Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros, Goiânia, GO, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil. | en_US |
| Subject | Zika virus | en_US |
| Subject | Asian lineage | en_US |
| Subject | Midwest Brazil | en_US |
| Subject | Genomic epidemiology | en_US |
