| Author | Palomino, Miriam | |
| Author | Pinto, Jesus | |
| Author | Yãnez, Pamela | |
| Author | Cornello, Anali | |
| Author | Dias, Luciana | |
| Author | Amorim, Quesia | |
| Author | Martins, Ademir Jesus | |
| Author | Lenhart, Audrey | |
| Author | Lima, Jose Bento Pereira | |
| Access date | 2022-12-25T20:56:23Z | |
| Available date | 2022-12-25T20:56:23Z | |
| Document date | 2022 | |
| Citation | PALOMINO, Miriam et al. First national‑scale evaluation of temephos resistance in Aedes aegypti in Peru. Parasites & Vectors, v. 15, n. 254, p. 1 - 13, 2022. | en_US |
| ISSN | 1756-3305 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56196 | |
| Language | eng | en_US |
| Publisher | BMC | en_US |
| Rights | open access | |
| Subject in Portuguese | Primeira avaliação | en_US |
| Subject in Portuguese | Escala nacional | en_US |
| Subject in Portuguese | Resistência do temefós | en_US |
| Subject in Portuguese | Aedes aegypti | en_US |
| Subject in Portuguese | Peru | en_US |
| Subject in Portuguese | Resistência a inseticidas | en_US |
| Subject in Portuguese | Controle de vetores | en_US |
| Subject in Portuguese | Taxa de resistência (RR) | en_US |
| Subject in Portuguese | Arbovírus | en_US |
| Title | First national‑scale evaluation of temephos resistance in Aedes aegypti in Peru | en_US |
| Type | Article | |
| DOI | 10.1186/s13071-022-05310-x | |
| Abstract | Background: The development of resistance against insecticides in Aedes aegypti can lead to operational failures in
control programs. Knowledge of the spatial and temporal trends of this resistance is needed to drive effective monitoring
campaigns, which in turn provide data on which vector control decision-making should be based.
Methods: Third-stage larvae (L3) from the F1 and F2 generations of 39 Peruvian field populations of Ae. aegypti
mosquitoes from established laboratory colonies were evaluated for resistance against the organophosphate insecticide
temephos. The 39 populations were originally established from eggs collected in the field with ovitraps in eight
departments of Peru during 2018 and 2019. Dose–response bioassays, at 11 concentrations of the insecticide, were
performed following WHO recommendations.
Results: Of the 39 field populations of Ae. aegypti tested for resistance to temephos , 11 showed high levels of resistance
(resistance ratio [RR] > 10), 16 showed moderate levels of resistance (defined as RR values between 5 and 10)
and only 12 were susceptible (RR < 5). The results segregated the study populations into two geographic groups. Most
of the populations in the first geographic group, the coastal region, were resistant to temephos, with three populations
(AG, CR and LO) showing RR values > 20 (AG 21.5, CR 23.1, LO 39.4). The populations in the second geographic
group, the Amazon jungle and the high jungle, showed moderate levels of resistance, with values ranging between
5.1 (JN) and 7.1 (PU). The exception in this geographic group was the population from PM, which showed a RR value
of 28.8 to this insecticide.
Conclusions: The results of this study demonstrate that Ae. aegypti populations in Peru present different resistance
intensities to temephos, 3 years after temephos use was discontinued. Resistance to this larvicide should continue to
be monitored because it is possible that resistance to temephos could decrease in the absence of routine selection
pressures. | en_US |
| Affilliation | Instituto Nacional de Salud. Centro Nacional de Salud Pública. Laboratorio de Referencia Nacional de Entomologia. Lima, Peru / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores‑LAFICAVE. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Instituto Nacional de Salud. Centro Nacional de Salud Pública. Laboratorio de Referencia Nacional de Entomologia. Lima, Peru. | en_US |
| Affilliation | Instituto Nacional de Salud. Centro Nacional de Salud Pública. Laboratorio de Referencia Nacional de Entomologia. Lima, Peru. | en_US |
| Affilliation | Instituto Nacional de Salud. Centro Nacional de Salud Pública. Laboratorio de Referencia Nacional de Entomologia. Lima, Peru. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores‑LAFICAVE. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores‑LAFICAVE. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores‑LAFICAVE. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores‑LAFICAVE. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | First national‑scale | en_US |
| Subject | Evaluation of temephos resistance | en_US |
| Subject | Aedes aegypti | en_US |
| Subject | Peru | en_US |
| Subject | Arboviruses | en_US |
| Subject | Insecticide resistance | en_US |
| Subject | Vector control | en_US |
| Subject | Resistance ratio (RR) | en_US |
