| Author | Monteiro, Wuelton | |
| Author | Karl, Stephan | |
| Author | Kuehn, Andrea | |
| Author | Almeida, Anne | |
| Author | White, Michael | |
| Author | Vitor-Silva, Sheila | |
| Author | Melo, Gisely | |
| Author | Brito-Sousa, Jose Diego | |
| Author | Baia-da-Silva, Djane Clarys | |
| Author | Silva-Neto, Alexandre Vilhena | |
| Author | Sampaio, Vanderson | |
| Author | Bassat, Quique | |
| Author | Felger, Ingrid | |
| Author | Mueller, Ivo | |
| Author | Lacerda, Marcus | |
| Access date | 2023-01-04T01:49:12Z | |
| Available date | 2023-01-04T01:49:12Z | |
| Document date | 2022 | |
| Citation | MONTEIRO, Wuelton et al. Prevalence and force of Plasmodium vivax blood-stage infection and associated clinical malaria burden in the Brazilian Amazon. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, p. 1-9, 2022. | en_US |
| ISSN | 0074-0276 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56309 | |
| Language | por | en_US |
| Publisher | Fiocruz/IOC | en_US |
| Rights | open access | en_US |
| Title | Prevalence and force of Plasmodium vivax blood-stage infection and associated clinical malaria burden in the Brazilian Amazon | en_US |
| Type | Article | en_US |
| DOI | 10.1590/0074-02760210330 | |
| Abstract | BACKGROUND: Understanding the epidemiology of malaria through the molecular force of the blood-stage infection of Plasmodium vivax (molFOB) may provide a detailed assessment of malaria transmission. OBJECTIVES: In this study, we investigated risk factors and spatial-temporal patterns of incidence of Plasmodium infection and clinical malaria episodes in three peri-urban communities of Manaus, Western Brazilian Amazon. METHODS: Monthly samples were collected in a cohort of 1,274 individuals between April 2013 and March 2014. DNA samples were subject to Plasmodium species. molFOB was calculated by counting the number of genotypes observed on each visit, which had not been present in the preceding two visits and adjusting these counts by the respective times-at-risk. FINDINGS: Respectively, 77.8% and 97.2% of the population remained free of P. vivax and P. falciparum infection. Expected heterozygosity for P. vivax was 0.69 for MSP1_F3 and 0.86 for MS2. Multiplicity of infection in P. vivax was close to the value of 1. The season was associated with P. vivax positivity [adjusted hazard ratio (aHR) 2.6 (1.9-5.7)] and clinical disease [aHR 10.6 (2.4-
47.2)]. P. falciparum infection was associated with previous malarial episodes [HR 9.7 (4.5-20.9)]. Subjects who reported possession of a bed net [incidence rate ratio (IRR) 1.6 (1.2-2.2)] or previous malaria episodes [IRR 3.0 (2.0-4.5)] were found to have significantly higher P. vivax molFOB. MAIN CONCLUSIONS: Overall, P. vivax infection prevailed in the area and infections were mostly observed as monoclonal. Previous malaria episodes were associated with significantly higher P. vivax molFOB. | |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil. | en_US |
| Affilliation | Walter and Eliza Hall Institute of Medical Research. Victoria, Australia / Papua New Guinea Institute of Medical Research. Vector-Borne Diseases Unit. Madang, Papua New Guinea / Melbourne University. Department of Medical Biology. Victoria, Australia. | |
| Affilliation | Universitat de Barcelona. Barcelona Institute for Global Health. Hospital Clínic. Barcelona, Spain. | |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil. | |
| Affilliation | Walter and Eliza Hall Institute of Medical Research. Victoria, Australia / Institut Pasteur. Department of Parasites and Insect Vectors, Malaria, Parasites and Hosts. Paris, France. | |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil. | |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil. | |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil. | |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil. | |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil. | |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil. | |
| Affilliation | Universitat de Barcelona. Barcelona Institute for Global Health. Hospital Clínic. Barcelona, Spain / Centro de Investigação em Saúde de Manhiça. Maputo, Mozambique / Catalan Institution for Research and Advanced Studies. Pg Lluís Companys. Barcelona, Spain / University of Barcelona. Hospital Sant Joan Déu. Pediatric Infectious Diseases Unit. Pediatrics Department. Barcelona, Spain. | |
| Affilliation | Swiss Tropical and Public Health Institute. Basel, Switzerland / University of Basel. Basel, Switzerland. | |
| Affilliation | Walter and Eliza Hall Institute of Medical Research. Victoria, Australia / Papua New Guinea Institute of Medical Research. Vector-Borne Diseases Unit. Madang, Papua New Guinea / Universitat de Barcelona. Barcelona Institute for Global Health. Hospital Clínic. Barcelona, Spain / Institut Pasteur. Department of Parasites and Insect Vectors, Malaria, Parasites and Hosts. Paris, France. | |
| Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Manaus, AM, Brasil. | |
| Subject | Molecular force of blood-stage infection | |
| Subject | Plasmodium vivax | |
| Subject | Malaria transmission | |
| e-ISSN | 1678-8060 | |
