| Author | Azevedo, Sophia Lincoln Cardoso de | |
| Author | Catanho, Marcos | |
| Author | Guimarães, Ana Carolina Ramos | |
| Author | Galvão, Teca Calcagno | |
| Access date | 2023-01-04T18:51:25Z | |
| Available date | 2023-01-04T18:51:25Z | |
| Document date | 2022 | |
| Citation | AZEVEDO, Sophia Lincoln Cardoso de et al. Genomic surveillance: a potential shortcut for effective Chagas disease management. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e220164, p. 1-8, July 2022. | en_US |
| ISSN | 0074-0206 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56323 | |
| Language | eng | en_US |
| Publisher | Fiocruz/IOC | en_US |
| Rights | open access | |
| Subject in Portuguese | Doença de Chagas | en_US |
| Subject in Portuguese | Trypanosoma cruzi | en_US |
| Subject in Portuguese | Sequenciamento completo do genoma | en_US |
| Subject in Portuguese | Variação genética | en_US |
| Subject in Portuguese | Agentes tripanocidas | en_US |
| Subject in Portuguese | Biologia Computacional | en_US |
| Title | Genomic surveillance: a potential shortcut for effective Chagas disease management | en_US |
| Type | Article | |
| DOI | 10.1590/0074-02760220164 | |
| Abstract | Chagas disease is an enduring public health issue in many Latin American countries, receiving insufficient investment in research and development. Strategies for disease control and management currently lack efficient pharmaceuticals, commercial diagnostic kits with improved sensitivity, and vaccines. Genetic heterogeneity of Trypanosoma cruzi is a key aspect for novel drug design since pharmacological technologies rely on the degree of conservation of parasite target proteins. Therefore, there is a need to expand the knowledge regarding parasite genetics which, if fulfilled, could leverage Chagas disease research and development, and improve disease control strategies. The growing capacity of whole-genome sequencing technology and its adoption as disease surveillance routine may be key for solving this long-lasting problem. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Niterói, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Chagas disease | en_US |
| Subject | Trypanosoma cruzi | en_US |
| Subject | Whole genome sequencing | en_US |
| Subject | Genetic variation | en_US |
| Subject | Trypanocidal agents | en_US |
| Subject | Computational biology | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
