| Author | Silva, Thaís de Souza | |
| Author | Salvato, Richard Steiner | |
| Author | Gregianini, Tatiana Schäffer | |
| Author | Gomes, Ighor Arantes | |
| Author | Pereira, Elisa Cavalcante | |
| Author | Oliveira, Eneida de | |
| Author | Menezes, André Luiz de | |
| Author | Barcellos, Regina Bones | |
| Author | Godinho, Fernanda Marques | |
| Author | Riediger, Irina | |
| Author | Debur, Maria do Carmo | |
| Author | Oliveira, Cristina Mendes de | |
| Author | Ribeiro-Rodrigues, Rodrigo | |
| Author | Miyajima, Fabio | |
| Author | Dias, Fernando Stehling | |
| Author | Abbud, Adriano | |
| Author | Monte Neto, Rubens Lima do | |
| Author | Silva, Carlos Eduardo Calzavara | |
| Author | Siqueira, Marilda Mendonça | |
| Author | Wallau, Gabriel Luz | |
| Author | Resende, Paola Cristina | |
| Author | Fernandes, Gabriel da Rocha | |
| Author | Alves, Pedro Augusto | |
| Access date | 2023-01-05T19:16:31Z | |
| Available date | 2023-01-05T19:16:31Z | |
| Document date | 2022 | |
| Citation | SILVA, Thaís de Souza et al. Molecular characterization of a new SARS-CoV-2 recombinant cluster XAG identified in Brazil. Frontiers in Medicine, v. 9, 1008600, p. 1-10, Sept. 2022. | en_US |
| ISSN | 2296-858X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56337 | |
| Description | A Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/ | |
| Language | eng | en_US |
| Publisher | Frontiers Media S.A | en_US |
| Rights | open access | |
| Title | Molecular characterization of a new SARS-CoV-2 recombinant cluster XAG identified in Brazil | en_US |
| Type | Article | |
| DOI | 10.3389/fmed.2022.1008600 | |
| Abstract | Recombination events have been described in the Coronaviridae family. Since the beginning of the SARS-CoV-2 pandemic, a variable degree of selection pressure has acted upon the virus, generating new strains with increased fitness in terms of viral transmission and antibody scape. Most of the SC2 variants of concern (VOC) detected so far carry a combination of key amino acid changes and indels. Recombination may also reshuffle existing genetic profiles of distinct strains, potentially giving origin to recombinant strains with altered phenotypes. However, co-infection and recombination events are challenging to detect and require in-depth curation of assembled genomes and sequencing reds. Here, we present the molecular characterization of a new SARS-CoV-2 recombinant between BA.1.1 and BA.2.23 Omicron lineages identified in Brazil. We characterized four mutations that had not been previously described in any of the recombinants already identified worldwide and described the likely breaking points. Moreover, through phylogenetic analysis, we showed that the newly named XAG lineage groups in a highly supported monophyletic clade confirmed its common evolutionary history from parental Omicron lineages and other recombinants already described. These observations were only possible thanks to the joint effort of bioinformatics tools auxiliary in genomic surveillance and the manual curation of experienced personnel, demonstrating the importance of genetic, and bioinformatic knowledge in genomics. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Estado do Rio Grande do Sul. Laboratório Central de Saúde Pública. Porto Alegre, RS, Brazil. | en_US |
| Affilliation | Estado do Rio Grande do Sul. Laboratório Central de Saúde Pública. Porto Alegre, RS, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Prefeitura de Belo Horizonte. Laboratório de Referência. Setor de Biologia Molecular. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Prefeitura de Belo Horizonte. Laboratório de Referência. Setor de Biologia Molecular. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brazil. | en_US |
| Affilliation | Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brazil. | en_US |
| Affilliation | Estado do Paraná. Laboratório Central de Saúde Pública. Curitiba, PR, Brazil. | en_US |
| Affilliation | Estado do Paraná. Laboratório Central de Saúde Pública. Curitiba, PR, Brazil. | en_US |
| Affilliation | Dasa. Barueri, SP, Brazil. | en_US |
| Affilliation | Estado do Espírito Santo. Laboratório Central de Saúde Pública. Vitória, ES, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Ceará. Eusébio, CE, Brazil. | en_US |
| Affilliation | Instituto Adolfo Lutz. São Paulo, SP, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | Recombinant | R |
| Subject | Genomic surveillance | en_US |
| Subject | XAG | en_US |
| Subject | Variants | en_US |
| Subject | Omicron | en_US |
