| Autor | Oliveira, Pedro Dantas | |
| Autor | Ribeiro, Guilherme Sousa | |
| Autor | Anjos, Rosangela Oliveira | |
| Autor | Dias, Maria Almeida | |
| Autor | Farre, Lourdes | |
| Autor | Araújo, Iguaracyra | |
| Autor | Bittencourt, Achiléa Lisboa | |
| Data de acesso | 2023-01-06T14:39:21Z | |
| Data de disponibilização | 2023-01-06T14:39:21Z | |
| Data do publicação | 2022 | |
| Citação | OLIVEIRA, Pedro Dantas et al. The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis. Plos Neglected Tropical Diseases, v. 16, n. 10, p. 1-14, 2022. | en_US |
| ISSN | 1935-2735 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56350 | |
| Fomento | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Fundação de Apoio à Pesquisa do Estado da Bahia (FAPESB). | en_US |
| Idioma | eng | en_US |
| Editor | Public Library of Science | en_US |
| Direito Autoral | open access | en_US |
| Palavras-chave | Leucemia | en_US |
| Palavras-chave | Linfoma de células T | en_US |
| Palavras-chave | Classificação clínica | en_US |
| Palavras-chave | Prognóstico | en_US |
| Título | The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis | en_US |
| Tipo do documento | Article | en_US |
| DOI | 10.1371/journal.pntd.0010807 | |
| Resumo em Inglês | ackground: Adult T-cell leukemia/lymphoma (ATLL), a peripheral T-cell leukemia/lymphoma associated with the human T-cell lymphotropic virus type-1 (HTLV-1), has been classified following the clinical forms defined by Shimoyama in 1991. A suggestion to modify Shimoyama's classification was proposed in 2007 to differentiate within the smoldering patients those who presented nodules or tumors in the skin without lung involvement, which was named the primary cutaneous tumoral (PCT) form of ATLL. In the present study, according to their clinicopathological characteristics, we estimated the mortality rates of 143 ATLL patients from Bahia, Brazil. We also evaluated the importance of classifying PCT/ATLL separately from the smoldering type on disease prognosis. Methodology/principal findings: Diagnosis of ATLL was established based on a positive serology for HTLV-1, histopathological and/or cytological diagnosis of peripheral T-cell leukemia/lymphoma. Patients were clinically grouped according to Shimoyama's classification, considering PCT variants separately from the smoldering cases. Bivariate and multivariable survival analyses were applied to identify factors associated with disease prognosis. Significant differences in the median survival time were observed between the clinical types, with the smoldering type presenting the longest median survival (109 months) compared to the other forms (<50 months); the median survival for PCT/ATLL was 20 months. Multivariable analysis confirmed that ATLL clinical types were associated with survival, with a better prognosis for patients with the smoldering and chronic types. Furthermore, skin involvement was related to a worse outcome in the multivariable analysis, regardless of the clinical form and presence of lymphadenopathy. Conclusions/significance: Our results reinforce the importance of considering the PCT/ATLL separately from the smoldering type when classifying ATLL to better define prognosis and treatment, given the significant difference in the survival of patients between the smoldering form and PCT/ATLL. Skin involvement should also be considered an independent prognostic factor in patients with ATLL. | en_US |
| Afiliação | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Clínica Médica. Salvador, BA, Brasil / Universidade Federal de Sergipe. Departamento de Medicina. Aracaju, SE, Brasil. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Medicina Preventiva e Social. Salvador, BA, Brasil. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil. | en_US |
| Afiliação | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Clínica Médica. Salvador, BA, Brasil. | en_US |
| Afiliação | Oswaldo Cruz Fundação. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil / Program Against Cancer Therapeutic Resistance. Catalan Institute of Oncology. ONCOBELL. Bellvitge Institute for Biomedical Research. L’Hospitalet del Llobregat. Catalonia, Spain, | en_US |
| Afiliação | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Patologia, Salvador, BA, Brasil. | en_US |
| Afiliação | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Patologia, Salvador, BA, Brasil. | en_US |
| Palavras-chave em inglês | T-cell leukemia | en_US |
| Palavras-chave em inglês | Lymphoma | en_US |
| Palavras-chave em inglês | Clinical classification | en_US |
| Palavras-chave em inglês | Prognosis | en_US |
| DeCS | Leucemia | en_US |
| DeCS | Linfoma de células T | en_US |
| DeCS | Classificação | en_US |
| DeCS | Prognóstico | en_US |
