| Author | Prete Jr, Carlos A. | |
| Author | Buss, Lewis F. | |
| Author | Whittaker, Charles | |
| Author | Salomon, Tassila | |
| Author | Oikawa, Marcio K. | |
| Author | Pereira, Rafael H. M. | |
| Author | Moura, Isabel C. G. | |
| Author | Delerino, Lucas | |
| Author | Barral Netto, Manoel | |
| Author | Tavares, Natalia M. | |
| Author | Franca, Rafael F. O | |
| Author | Boaventura, Viviane S. | |
| Author | Miyajima, Fabio | |
| Author | Mendrone Junior, Alfredo | |
| Author | Almeida Neto, Cesar de | |
| Author | Salles, Nanci A. | |
| Author | Ferreira, Suzete C. | |
| Author | Fladzinski, Karine A. | |
| Author | Souza, Luana M. de | |
| Author | Schier, Luciane K. | |
| Author | Inoue, Patricia M. | |
| Author | Xabregas, Lilyane A. | |
| Author | Crispim, Myuki A. E. | |
| Author | Fraiji, Nelson | |
| Author | Araujo, Fernando L. V. | |
| Author | Carlos, Luciana M. B | |
| Author | Pessoa, Veridiana | |
| Author | Ribeiro, Maisa A. | |
| Author | Souza, Rosenvaldo E. de | |
| Author | Silva, Sônia M. N. da | |
| Author | Cavalcante, Anna F. | |
| Author | Valença, Maria I. B | |
| Author | Silva, Maria V. da | |
| Author | Lopes, Esther | |
| Author | Melo Filho, Luiz Amorim de | |
| Author | Mateos, Sheila O. G. | |
| Author | Nunes, Gabrielle T. | |
| Author | Silva Junior, Alexander L. | |
| Author | Busch, Michael P. | |
| Author | Castro, Marcia C. | |
| Author | Dye, Christopher | |
| Author | Ratmann, Oliver | |
| Author | Faria, Nuno R. | |
| Author | Nascimento, Vítor H. | |
| Author | Sabino, Ester C. | |
| Access date | 2023-01-06T18:27:15Z | |
| Available date | 2023-01-06T18:27:15Z | |
| Document date | 2022 | |
| Citation | PRETE JR, Carlos A. et al. SARS-CoV- 2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals: a serial cross-sectional study. eLife, v. 11, p. 1-53, 2022. | en_US |
| ISSN | 2050-084X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56355 | |
| Sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).
Todos pela Saúde do Itaú Unibanco.
Wellcome Trust and Royal Society Sir Henry Dale Fellowship.
Fundação Gates.
UK Medical Research Council.
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Fundação Faculdade de Medicina
Programa Inova Fiocruz-CE/Funcap. | en_US |
| Language | eng | en_US |
| Publisher | eLife Sciences Publications | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | COVID-19 | en_US |
| Subject in Portuguese | SARS-CoV-2 | en_US |
| Subject in Portuguese | Taxa de ataque | en_US |
| Subject in Portuguese | Doadores de sangue | en_US |
| Subject in Portuguese | Epidemiologia | en_US |
| Subject in Portuguese | Saúde global | en_US |
| Subject in Portuguese | Taxa de mortalidade por infecção | en_US |
| Subject in Portuguese | Sorovigilância | en_US |
| Subject in Portuguese | Vírus | en_US |
| Title | SARS-CoV- 2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals: a serial cross-sectional study | en_US |
| Type | Article | en_US |
| DOI | 10.7554/eLife.78233. | |
| Abstract | Background: The COVID-19 situation in Brazil is complex due to large differences in the shape and size of regional epidemics. Understanding these patterns is crucial to understand future outbreaks of SARS-CoV-2 or other respiratory pathogens in the country. Methods: We tested 97,950 blood donation samples for IgG antibodies from March 2020 to March 2021 in 8 of Brazil's most populous cities. Residential postal codes were used to obtain representative samples. Weekly age- and sex-specific seroprevalence were estimated by correcting the crude seroprevalence by test sensitivity, specificity, and antibody waning. Results: The inferred attack rate of SARS-CoV-2 in December 2020, before the Gamma variant of concern (VOC) was dominant, ranged from 19.3% (95% credible interval [CrI] 17.5-21.2%) in Curitiba to 75.0% (95% CrI 70.8-80.3%) in Manaus. Seroprevalence was consistently smaller in women and donors older than 55 years. The age-specific infection fatality rate (IFR) differed between cities and consistently increased with age. The infection hospitalisation rate increased significantly during the Gamma-dominated second wave in Manaus, suggesting increased morbidity of the Gamma VOC compared to previous variants circulating in Manaus. The higher disease penetrance associated with the health system's collapse increased the overall IFR by a minimum factor of 2.91 (95% CrI 2.43-3.53). Conclusions: These results highlight the utility of blood donor serosurveillance to track epidemic maturity and demonstrate demographic and spatial heterogeneity in SARS-CoV-2 spread. | en_US |
| Affilliation | Universidade de São Paulo. Departamento de Engenharia de Sistemas Eletrônicos. São Paulo, SP, Brasil. | en_US |
| Affilliation | Imperial College London. London, United Kingdom. | en_US |
| Affilliation | MRC Centre for Global Infectious Disease Analysis. Imperial College London. London, United Kingdom / Abdul Latif Jameel Institute for Disease and Emergency Analytics. Imperial College London. London, United Kingdom. | en_US |
| Affilliation | Faculdade Ciências Médicas de Minas Gerais. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal do ABC. São Bernardo do Campo, SP, Brasil. | en_US |
| Affilliation | Instituto de Pesquisa Econômica Aplicada. Brasília, DF, Brasil. | en_US |
| Affilliation | Faculdade Ciências Médicas de Minas Gerais. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Universidade Federal do Ceará. Fortaleza, CE, Brasil. | en_US |
| Affilliation | Fundação Pró-sangue Hemocentro de São Paulo. São Paulo, SP, Brasil. | en_US |
| Affilliation | Fundação Pró-sangue Hemocentro de São Paulo. São Paulo, SP, Brasil. | en_US |
| Affilliation | Fundação Pró-sangue Hemocentro de São Paulo. São Paulo, SP, Brasil. | en_US |
| Affilliation | Fundação Pró-sangue Hemocentro de São Paulo. São Paulo, SP, Brasil. | en_US |
| Affilliation | Centro de Hematologia e Hemoterapia do Paraná. Curitiba, PR, Brasil. | en_US |
| Affilliation | Centro de Hematologia e Hemoterapia do Paraná. Curitiba, PR, Brasil. | en_US |
| Affilliation | Centro de Hematologia e Hemoterapia do Paraná. Curitiba, PR, Brasil. | en_US |
| Affilliation | Centro de Hematologia e Hemoterapia do Paraná. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil. | en_US |
| Affilliation | Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil. | en_US |
| Affilliation | Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil. | en_US |
| Affilliation | Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Centro de Hematologia e Hemoterapia do Ceará. Fortaleza, CE, Brasil. | en_US |
| Affilliation | Centro de Hematologia e Hemoterapia do Ceará. Fortaleza, CE, Brasil. | en_US |
| Affilliation | Fundação HEMOMINAS. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação HEMOMINAS. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação HEMOMINAS. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação de Hematologia e Hemoterapia de Pernambuco. Recife, PE, Brasil. | en_US |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil | en_US |
| Affilliation | Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil / Universidade Federal do Amazonas. Manaus, AM, Brasil / Centro Universitário do Norte. Manaus, AM, Brasil. | en_US |
| Affilliation | Vitalant Research Institute. San Francisco, United States / University of California. San Francisco, United States. | en_US |
| Affilliation | Harvard TH Chan School of Public Health. Boston, United States. | en_US |
| Affilliation | Department of Zoology. University of Oxford. Oxford, United Kingdom. | en_US |
| Affilliation | Imperial College London. London, United Kingdom. | en_US |
| Affilliation | Imperial College London. London, United Kingdom / MRC Centre for Global Infectious Disease Analysis. Imperial College London. London, United Kingdom / Department of Zoology. University of Oxford. Oxford, United Kingdom / Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil. | en_US |
| Affilliation | Universidade de São Paulo. Departamento de Engenharia de Sistemas Eletrônicos. São Paulo, SP, Brasil. | en_US |
| Affilliation | Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil. | en_US |
| Subject | COVID-19 | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | Attack rate | en_US |
| Subject | Blood donors | en_US |
| Subject | Epidemiology | en_US |
| Subject | Global health | en_US |
| Subject | Infection fatality rate | en_US |
| Subject | Serosurveillance | en_US |
| Subject | Viruses | en_US |
| DeCS | COVID-19 | en_US |
| DeCS | SARS-CoV-2 | en_US |
| DeCS | Incidência | en_US |
| DeCS | Doadores de Sangue | en_US |
| DeCS | Epidemiologia | en_US |
| DeCS | Saúde global | en_US |
| DeCS | Mortalidade | en_US |
| DeCS | Vírus | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
