| Author | Santos, Caroline Fernandes | |
| Author | Azeredo, Elzinandes Leal de | |
| Access date | 2023-01-08T11:53:42Z | |
| Available date | 2023-01-08T11:53:42Z | |
| Document date | 2022 | |
| Citation | SANTOS, Caroline Fernandes; AZEREDO, Elzinandes Leal de. Innate Immune Response to Dengue Virus: Toll-like Receptors and Antiviral Response. Viruses, v. 14, 992, p. 1-21, May 2022. | en_US |
| ISSN | 1999-4915 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56376 | |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | |
| Subject in Portuguese | Receptores do tipo pedágio | en_US |
| Subject in Portuguese | Vírus da dengue | en_US |
| Subject in Portuguese | Imunidade inata | en_US |
| Subject in Portuguese | Resposta antiviral | en_US |
| Subject in Portuguese | Citocinas | en_US |
| Subject in Portuguese | Interferons | en_US |
| Title | Innate Immune Response to Dengue Virus: Toll-like Receptors and Antiviral Response | en_US |
| Type | Article | |
| DOI | 10.3390/v14050992 | |
| Abstract | Dengue is a mosquito-borne viral disease caused by the dengue virus (DENV1-4). The
clinical manifestations range from asymptomatic to life-threatening dengue hemorrhagic fever (DHF)
and/or Dengue Shock Syndrome (DSS). Viral and host factors are related to the clinical outcome
of dengue, although the disease pathogenesis remains uncertain. The innate antiviral response to
DENV is implemented by a variety of immune cells and inflammatory mediators. Blood monocytes,
dendritic cells (DCs) and tissue macrophages are the main target cells of DENV infection. These cells
recognize pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors
(PRRs). Pathogen recognition is a critical step in eliciting the innate immune response. Toll-like
receptors (TLRs) are responsible for the innate recognition of pathogens and represent an essential
component of the innate and adaptive immune response. Ten different TLRs are described in humans,
which are expressed in many different immune cells. The engagement of TLRs with viral PAMPs
triggers downstream signaling pathways leading to the production of inflammatory cytokines,
interferons (IFNs) and other molecules essential for the prevention of viral replication. Here, we
summarize the crucial TLRs’ roles in the antiviral innate immune response to DENV and their
association with viral pathogenesis. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Toll-like receptors | en_US |
| Subject | Dengue virus | en_US |
| Subject | Innate immunity | en_US |
| Subject | Antiviral response | en_US |
| Subject | Cytokines | en_US |
| Subject | Interferons | en_US |
