| Author | Conde, Luciana | |
| Author | Maciel, Gabriela | |
| Author | Assis, Gustavo Meira de | |
| Author | Lima, Leonardo Freire de | |
| Author | Nico, Dirlei | |
| Author | Vale, André | |
| Author | LIma, Célio Geraldo Freire de | |
| Author | Morrot, Alexandre | |
| Access date | 2023-01-13T12:24:42Z | |
| Available date | 2023-01-13T12:24:42Z | |
| Document date | 2022 | |
| Citation | CONDE, Luciana et al. Humoral response in Leishmaniasis. Frontiers in Cellular and Infection Microbiology, v. 12, 1063291, p. 1 - 8, Dec. 2022. | en_US |
| ISSN | 2235-2988 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56453 | |
| Language | eng | en_US |
| Publisher | Frontiers Media | en_US |
| Rights | open access | |
| Subject in Portuguese | Leishmania | en_US |
| Subject in Portuguese | Resposta humoraL | en_US |
| Subject in Portuguese | Leishmaniose | en_US |
| Subject in Portuguese | Sistema de complemento | en_US |
| Subject in Portuguese | Linfócitos B | en_US |
| Title | Humoral response in Leishmaniasis | en_US |
| Type | Article | |
| DOI | 10.3389/fcimb.2022.1063291 | |
| Abstract | Leishmaniasis presents different types of clinical manifestations that can be
divided into cutaneous leishmaniasis and visceral leishmaniasis. The host’s
immune system, associated with genetic and nutritional factors, is strongly
involved in the evolution of the disease or parasite escape. Humoral immunity is
characterized by the production of antibodies capable of promoting
neutralization, opsonization, and activation of the complement system. In
this scenario, B lymphocytes produce antibodies that play an important role
in Leishmania infection although neglected for a long time. Thus, relevant
aspects in the establishment of Leishmania infection will be addressed,
highlighting the importance of humoral immunity during the entire process
of Leishmania infection. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Leishmania | en_US |
| Subject | Humoral response | en_US |
| Subject | Leishmaniasis | en_US |
| Subject | Complement system | en_US |
| Subject | B lymphocytes | en_US |
