| Author | Gonzaga, Beatriz Matheus Souza | |
| Author | Horita, Samuel Iwao Maia | |
| Author | Beghini, Daniela Gois | |
| Author | Gomes, Fabiana | |
| Author | Nisimura, Líndice Mitie | |
| Author | Santos, Isabele Barbieri dos | |
| Author | Estato, Vanessa | |
| Author | Araujo-Jorge, Tania Cremonini de | |
| Author | Garzoni, Luciana Ribeiro | |
| Access date | 2023-01-15T13:14:09Z | |
| Available date | 2023-01-15T13:14:09Z | |
| Document date | 2022 | |
| Citation | GONZAGA, Beatriz Matheus Souza et al. Effect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice. Scientific Reports, v. 12, n. 21048, p. 1-11, 2022. | |
| ISSN | 2045-2322 | |
| URI | https://www.arca.fiocruz.br/handle/icict/56468 | |
| Description | Produção científica do Laboratório de Imunofarmacologia. | pt_BR |
| Description | Produção científica do Laboratório de Inovações em Terapias, Ensino e Bioprodutos. | pt_BR |
| Description | Produção científica do Laboratório de Pesquisa em Malária. | pt_BR |
| Language | eng | en_US |
| Publisher | Nature Portfolio | |
| Rights | open access | |
| Subject in Portuguese | Efeito do benznidazol | pt_BR |
| Subject in Portuguese | Microcirculação cerebral | pt_BR |
| Subject in Portuguese | Durante a Infecção por Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Camundongos | pt_BR |
| Title | Effect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice | en_US |
| Type | Article | |
| DOI | 10.1038/s41598-022-25056-x | |
| Abstract | Central nervous system alterations was described in Chagas disease in both human and experimental models, leading to meningoencephalitis, stroke and cognitive impairment. Recently, our group demonstrated that acute infection by Trypanossoma cruzi leads to cerebral microvasculophaty in mice with endothelial dysfunction, capillary rarefaction, increased rolling and leukocyte adhesion. Only benznidazole and nifurtimox are available for clinical treatment, they have an efficiency of 80% in the acute phase and less than 20% in chronic phase. However, the effect of these drugs on brain microcirculation has not yet been evaluated. We hypothesized that early treatment with benznidazole could protect brain microcirculation during acute experimental Chagas disease. Swiss Webster mice were inoculated with 104 trypomastigotes forms of T. cruzi, and after 24 h they were treated with 50 or 100 mg/kg/day of benznidazole for 14 consecutive days. In untreated infected mice, we observed cerebral microvascular rarefaction, increase in leukocyte rolling and adhesion, reduced cerebral blood flow, and increased CD3+ and F4-80+ cells in brain tissue. Early treatment with benznidazole at 100 mg/kg/day and 50 mg/kg/day prevented the occurrence of the alterations mentioned. Here, we show that BZ is able to protect the microcirculation and reduced brain inflammation in acute experimental Chagas disease. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações Em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações Em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações Em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Pesquisa em Apicomplexa. Curitiba, PR, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Biotério do Pavilhão Carlos Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações Em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | |
| Subject | Effect of benznidazole | en_US |
| Subject | Cerebral microcirculation | en_US |
| Subject | Infection in mice | en_US |
| Subject | During Acute Trypanosoma cruzi | en_US |
| e-ISSN | 2045-2322 | |
