| Autor | Miranda, Cláudia Madeira | |
| Autor | Silva, Rose Mary Ferreira Lisboa da | |
| Autor | Pascoal, Vanessa Peruhybe Magalhães | |
| Autor | Brugada, Josep | |
| Data de acesso | 2023-01-19T15:40:32Z | |
| Data de disponibilização | 2023-01-19T15:40:32Z | |
| Data do publicação | 2022 | |
| Citação | MIRANDA, Cláudia Madeira et al. Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study. Clin Med Insights Cardiol., v. 16, 11795468221116848, 2022. doi: 10.1177/11795468221116848. | en_US |
| ISSN | 1179-5468 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56514 | |
| Idioma | eng | en_US |
| Editor | SAGE Publications | en_US |
| Direito Autoral | open access | en_US |
| Título | Vasoactive Biomarkers in Patients With Vasovagal Syncope During Head-Up Tilt Test: A Case-Control Study | en_US |
| Tipo do documento | Article | en_US |
| Resumo em Inglês | Background: Vasovagal syncope (VVS) is the most common cause of syncope. Some stages of its pathophysiological mechanisms remain unclear. Vasoactive substances such as nitric oxide metabolites (NOx) and endothelin (ET) may be involved during acute orthostatic stress.
Objective: To analyze plasma changes in NOx and ET and heart rate variability (HRV) in the supine positions (T1) and during the head-up tilt test (HUTT) (T2), in patients with VVS (case group) and control group.
Methods: Thirty-seven patients (17 in the case group and 20 in the control group), matched for age and sex (mean aged 31.8 years) underwent HUTT with simultaneous HRV recording and venipuncture. Blood samples were collected during phases T1 and T2 and the analysis was performed without knowledge of the HUTT result.
Results: In the total sample, there was an increase in NOx values (P = .014), however there was no increase in ET values from phase T1 to phase T2. Patients with VVS tended to increase plasma NOx values (P = .057) and had significantly higher plasma values compared to ET (P = .033) between phases T1 to T2. In the control group, there was no significant change in the values of these vasoactive substances. Regarding HRV, there were a decrease in the component HF (high frequency) and increased of the LF (low frequency)/HF ratio during HUTT.
Conclusions: There was an increase in ET during HUTT occurred only in the case group. These patients are more likely to have an imbalance between antagonistic vasoactive biomarkers during orthostatic stress. | en_US |
| Afiliação | Faculty of Medicine. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil/Madre Teresa Hospital. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Faculty of Medicine. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Oswaldo Cruz Foundation. René Rachou Institute. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Institut Clínic Cardiovascular. Hospital Clínic. Universitat de Barcelona. Barcelona, Spain. | en_US |
| Palavras-chave em inglês | Vasovagal syncope | en_US |
| Palavras-chave em inglês | autonomic nervous system | en_US |
| Palavras-chave em inglês | endothelin | en_US |
| Palavras-chave em inglês | head-up tilt test | en_US |
| Palavras-chave em inglês | nitric oxide | en_US |
| Palavras-chave em inglês | vasoactive agents | en_US |
