Autor | Freitas, Luiz Antonio Rodrigues de | |
Autor | Mbow, M. Lamine | |
Autor | Estay, Monica | |
Autor | Bleyenberg, Julie A. | |
Autor | Titus, Richard G. | |
Data de acesso | 2012-10-05T17:53:04Z | |
Data de disponibilização | 2012-10-05T17:53:04Z | |
Data do publicação | 1999 | |
Citação | FREITAS, Luiz Antonio Rodrigues de et al. Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major. Parasite Immunology, v. 21, n. 5, p. 273-7, May 1999. | pt_BR |
ISSN | 0141-9838 | |
URI | https://www.arca.fiocruz.br/handle/icict/5651 | |
Idioma | eng | pt_BR |
Direito Autoral | open access | pt_BR |
Título | Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major. | pt_BR |
Tipo do documento | Article | pt_BR |
Resumo em Inglês | Prostaglandins of the E series inhibit the development of Th1 responses. When infected with Leishmania major, BALB/c mice fail to develop a Th1 response, but instead mount a Th2 response and die of the disease. Therefore, we treated L. major-infected BALB/c mice with indomethacin, which inhibits prostaglandin production. Indomethacin lessened disease severity (parasite burden and pathology), and promoted a Th1 response, but the mice still succumbed to infection. The explanation for these observations may be two-fold: (1) the beneficial effects of indomethacin were predominantly observed later in infection (beyond two weeks), a time at which indomethacin was unable to sufficiently block the development of a Th2 response; (2) indomethacin was unable to induce a Th1 response in BALB/c mice that was of the same magnitude as the Th1 response observed in C57BL/6 mice infected with L. major. | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil | pt_BR |
Afiliação | College of Veterinary Medicine and Biomedical Sciences. Colorado State University. Fort Collins USA | pt_BR |
Afiliação | College of Veterinary Medicine and Biomedical Sciences. Colorado State University. Fort Collins USA | pt_BR |
Afiliação | College of Veterinary Medicine and Biomedical Sciences. Colorado State University. Fort Collins USA | pt_BR |
Afiliação | College of Veterinary Medicine and Biomedical Sciences. Colorado State University. Fort Collins USA | pt_BR |
Palavras-chave em inglês | Leishmania Major | pt_BR |
Palavras-chave em inglês | Leishmaniasis | pt_BR |
Palavras-chave em inglês | Prostaglandins | pt_BR |
Palavras-chave em inglês | Cytokines | pt_BR |
Palavras-chave em inglês | Nitric Oxide | pt_BR |
DeCS | Antiprotozoários/uso terapêutico | pt_BR |
DeCS | Indometacina/uso terapêutico | pt_BR |
DeCS | Leishmania major | pt_BR |
DeCS | Leishmaniose Cutânea/quimioterapia | pt_BR |
DeCS | Células Th1/imunologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Inibidores de Ciclooxigenase/uso terapêutico | pt_BR |
DeCS | Progressão da Doença | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Imunidade Celular | pt_BR |
DeCS | Leishmaniose Cutânea/imunologia | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Camundongos Endogâmicos C57BL | pt_BR |
DeCS | Antagonistas de Prostaglandina/uso terapêutico | pt_BR |