| Author | Pessoa, Natália Lima | |
| Author | Diniz, Lilian Martins Oliveira | |
| Author | Andrade, Adriana de Souza | |
| Author | Kroon, Erna Geessien | |
| Author | Bentes, Aline Almeida | |
| Author | Campos, Marco Antônio | |
| Access date | 2023-01-23T19:00:48Z | |
| Available date | 2023-01-23T19:00:48Z | |
| Document date | 2021 | |
| Citation | PESSOA, Natália Lima et al. Children with sickle cell disease and severe COVID-19 presenting single nucleotide polymorphisms in innate immune response genes - A case report. EJHaem, v. 3, n. 1, p. 199-202, 2021. | en_US |
| ISSN | 2688-6146 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56565 | |
| Language | eng | en_US |
| Publisher | John Wiley & Sons | en_US |
| Rights | open access | en_US |
| Title | Children with sickle cell disease and severe COVID-19 presenting single nucleotide polymorphisms in innate immune response genes - A case report | en_US |
| Type | Article | en_US |
| DOI | 10.1002/jha2.325 | |
| Abstract | Here we report three clinical cases of children with sickle cell disease (SCD) and severe COVID-19 who evolved with complications during hospitalization or after discharge. They present single nucleotide polymorphisms in tlr-7 and tirap genes, identified from 37 patients under 16 years old hospitalized from September 2020 to May 2021 in the Hospital João Paulo II, Belo Horizonte, Brazil. They presented significant complications of SCD as acute chest syndrome, splenic sequestration, and pain crisis during hospitalization or up to 2 months after SARS-CoV-2 infection. They all required transfusion of concentrated red blood cells and hospitalization in a reference hospital to care for children with SCD. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Vírus. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Pediatria. Belo Horizonte, MG, Brazil/Estado de Minas Geraisl. Fundação Hospitalar do Estado de Minas Gerais. Hospital João Paulo II. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Vírus. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Pediatria. Belo Horizonte, MG, Brazil/Estado de Minas Geraisl. Fundação Hospitalar do Estado de Minas Gerais. Hospital João Paulo II. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil. | en_US |
| Subject | COVID‐19 | en_US |
| Subject | TIRAP | en_US |
| Subject | TLR‐7 | en_US |
| Subject | Case report | en_US |
| Subject | Innate immunity | en_US |
| Subject | Sickle cell disease | en_US |
| Subject | Single nucleotide polymorphisms | en_US |
