| Author | Belisário, André Rolim | |
| Author | Oliveira, Franciane Mendes | |
| Author | Souza, Valquíria Reis de | |
| Author | Bolina-Santos, Eduarda | |
| Author | Mendes, Fabíola Gomes | |
| Author | Moreno, Elizabeth Castro | |
| Author | Franca, Alice Timponi | |
| Author | Sabino, Ester Cerdeira | |
| Author | Otta, Dayane Andriotti | |
| Author | Faria, Elaine Speziali de | |
| Author | Reis, Jordana Grazziela Alves Coelho dos | |
| Author | Martins Filho, Olindo Assis | |
| Author | Proietti, Anna Bárbara Carneiro | |
| Access date | 2023-01-24T13:35:27Z | |
| Available date | 2023-01-24T13:35:27Z | |
| Document date | 2022 | |
| Citation | ROLIM, Belisário, André et al. Association between inflammatory molecules, nitric oxide metabolites and leg ulcers in individuals with sickle cell anemia. Hematol Transfus Cell Ther., v. 44, n. 2, p. 169-176, 2022. doi: 10.1016/j.htct.2020.09.152. | en_US |
| ISSN | 2531-1379 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56572 | |
| Language | eng | en_US |
| Publisher | Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular | en_US |
| Rights | open access | en_US |
| Title | Association between inflammatory molecules, nitric oxide metabolites and leg ulcers in individuals with sickle cell anemia | en_US |
| Type | Article | en_US |
| Abstract | Objective: The aim of this study was to verify the association between inflammatory molecules and nitric oxide metabolites (NOx) and the occurrence of the LU in patients with SCA.
Method: It was a cross-sectional study on adult participants with SCA followed at Fundação Hemominas, a public blood center in Brazil. Eligible participants were recruited and included in one of two groups: Group 1, comprised of cases with SCA (Hb SS) and at least one LU at the time of inclusion in the study and Group 2, comprised of controls with SCA without a history of LU, matched by sex and age to cases. Participants were interviewed to obtain sociodemographic data and blood samples were collected. Clinical and laboratory data were abstracted from medical records. Nitric oxide metabolites (NOx) and inflammatory molecules were quantified using an immunoassay and Multiplex xMAP® technology, respectively. Eighty-seven individuals were included, ranging in age from 17 to 61 years (mean 40 ± 10.7 years); 30 had LU and 57 were controls without LU.
Results: Participants with LU had significantly higher levels of interleukin 8 (IL-8), IL-10, IL-15, NOx and platelet and white blood cell (WBC) counts, when compared to those without LU. Participants with LU had a significantly higher risk of having a history of osteomyelitis and a higher use of antiseptic soap in bathing, when compared to those without LU.
Conclusion: In conclusion, our results showed that NOx, inflammatory molecules and hematological features were associated with LU in Brazilian adults with SCA. | en_US |
| Affilliation | Estado de Minas Gerais. Fundação Hemominas. Centro de Tecidos Biológicos de Minas Gerais. Lagoa Santa, MG, Brazil | en_US |
| Affilliation | Estado de Minas Gerais. Fundação Hemominas. Serviço de Pesquisa. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Estado de Minas Gerais. Fundação Hemominas. Serviço de Pesquisa. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Estado de Minas Gerais. Fundação Hemominas. Serviço de Pesquisa. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Estado de Minas Gerais. Fundação Hemominas. Serviço de Pesquisa. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Estado de Minas Gerais. Fundação Hemominas. Serviço de Pesquisa. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Estado de Minas Gerais. Fundação Hemominas. Serviço de Pesquisa. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brazil/Instituto de Medicina Tropical. São Paulo, SP, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Estado de Minas Gerais. Fundação Hemominas. Centro de Tecidos Biológicos de Minas Gerais. Lagoa Santa, MG, Brazil | en_US |
| Subject | Inflammation | en_US |
| Subject | Leg ulcer | en_US |
| Subject | Nitric oxide | en_US |
| Subject | Sickle cell anemia | en_US |
