| Author | Lage, Anna Carolina Pinheiro | |
| Author | Ladeira, Luiz Orlando | |
| Author | Camo, Paulo Henrique Fonseca do | |
| Author | Amorim, Juliana Mendes | |
| Author | Monte Neto, Rubens Lima | |
| Author | Santos, Daniel Assis | |
| Author | Tunes, Luiza Guimarães | |
| Author | Castilho, Rachel Oliveira | |
| Author | Moreira, Paulo Otávio | |
| Author | Ferreira, Daniele Cristina | |
| Author | Silva, Diego Edison Lopez | |
| Author | Faraco, André Augusto Gomes | |
| Access date | 2023-01-26T15:56:20Z | |
| Available date | 2023-01-26T15:56:20Z | |
| Document date | 2022 | |
| Citation | LAGE, Anna Carolina Pinheiro et al. Changes in antiparasitical activity of gold nanorods according to the chosen synthesis. Experimental Parasitology, v. 242, 108367, 2022. Doi: 10.1016/j.exppara.2022.108367 | en_US |
| ISSN | 0014-4894 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56635 | |
| Language | eng | en_US |
| Publisher | Academic Press | en_US |
| Rights | restricted access | |
| Title | Changes in antiparasitical activity of gold nanorods according to the chosen synthesis | en_US |
| Type | Article | |
| Abstract | Gold nanorods (GNRs) are increasingly being studied for diagnostic and therapeutic purposes. Green synthesis based methods with natural compounds as additives stand out as a hope in terms of better synthesis methodology, with advantages of producing potentially less toxic and, perhaps, biologically active GNRs due to influence of natural additives used during synthesis. Exploring green chemistry using different natural phenolic compounds, the present work reveals different in vitro activity of GNRs evaluated against different parasites that causes skin infectious diseases compared to GNRs produced by convencional seed mediated method. This approach brings advantages in producing active GNRs, with ease calling, less cytotoxic and with a better selectivity index (SI) than GNRs synthesized by conventional seed mediated synthesis, opening new possibilities for therapies. Natural compounds used in green syntheses were gallic acid (GA), resveratrol (RSV) and a purified fraction of the hydroalcoholic extract of Stryphnodendron obovatum. GNRs exhibited great activity against Leishmania braziliensis, and the dermatophytes Tricophyton rubrum, T. interdigitale and Microsporum gypseum. The anti-Leishmania and antidermatophytic activity of GNRs reinforce the applicability of GNRs in biomedical field and the influence of synthesis method in biological activity, showing benefits related to the seedless synthesis with natural compounds. In addition, these preliminary results indicate the possibility of exploring at maximum the physical and chemical properties of GNRs in addition to the biological activity itself, such as the development of topical antiparasitic formulations for association with phototherapy. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmacêuticos. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Física. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmacêuticos. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmacêuticos. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Laboratório de Caracterização e de Processamento de Nanomateriais. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Laboratório de Caracterização e de Processamento de Nanomateriais. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmacêuticos. Belo Horizonte, MG, Brazil. | en_US |
| Subject | Dermatophytes | en_US |
| Subject | Gold nanorods | en_US |
| Subject | Green synthesis | en_US |
| Subject | Leishmania | en_US |
| Subject | Polyphenols | en_US |
| Embargo date | 2099-12-31 | |
