| Author | Martinho, Ana Clara Cassiano | |
| Author | Resende, Daniela de Melo | |
| Author | Landin, Emanuelly Silva | |
| Author | Lapierre, Thibault Joseph William Jacques Dit | |
| Author | Bernardes, Talita Cristina Diniz | |
| Author | Martins, Luan Carvalho | |
| Author | Ferreira, Rafaela Salgado | |
| Author | Murta, Silvane Maria Fonseca | |
| Author | Rezende Júnior, Celso de Oliveira | |
| Access date | 2023-01-26T16:21:47Z | |
| Available date | 2023-01-26T16:21:47Z | |
| Document date | 2022 | |
| Citation | MARTINHO, Ana Clara Cassiano et al. Synthesis, Design, and Structure‐Activity Relationship of a Benzenesulfonylpiperazine Series against Trypanosoma cruzi. ChemMedChem, v. 17, n. 19, p. e202200211, 2022. Doi: 10.1002/cmdc.202200211 | en_US |
| ISSN | 1860-7179 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56638 | |
| Language | eng | en_US |
| Publisher | Wiley-VCH | en_US |
| Rights | restricted access | |
| Title | Synthesis, Design, and Structure-Activity Relationship of a Benzenesulfonylpiperazine Series against Trypanosoma cruzi | en_US |
| Type | Article | |
| Abstract | Chagas disease is a neglected tropical disease, endemic in Latin America and caused by the protozoan parasite Trypanosoma cruzi. Available treatments show low cure efficacy during the chronic phase of the disease and cause a series of side effects, reinforcing the need to develop new drugs against Chagas disease. In this work, we describe the optimization of a trypanocidal hit compound recently reported in phenotypic high-throughput screening studies against Trypanosoma cruzi. A hit-to-lead process was initiated and a structure-activity relationship against Trypanosoma cruzi was obtained after the synthesis and biological evaluation of 22 new benzenesulfonylpiperazine derivatives. From this structure-activity relationship study, we identified three compounds with a promising predicted ADMET profile and potency comparable to the reference drug benznidazole, which are candidates for further development towards therapies for Chagas disease. | en_US |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Química. Laboratório de Síntese de Candidatos a Fármacos. Uberlândia, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Genômica Funcional de Parasitos. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Química. Laboratório de Síntese de Candidatos a Fármacos. Uberlândia, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Química. Laboratório de Síntese de Candidatos a Fármacos. Uberlândia, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Laboratório de Modelagem Molecular e Planejamento de Fármacos. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Laboratório de Modelagem Molecular e Planejamento de Fármacos. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Laboratório de Modelagem Molecular e Planejamento de Fármacos. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Genômica Funcional de Parasitos. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Química. Laboratório de Síntese de Candidatos a Fármacos. Uberlândia, MG, Brazil. | en_US |
| Subject | Benzenesulfonylpiperazines | en_US |
| Subject | Chagas disease | en_US |
| Subject | Drug discovery | en_US |
| Subject | Structure-activity relationship | en_US |
| Subject | Trypanosoma cruzi | en_US |
| Embargo date | 2099-12-31 | |
