Author | Silva, Gabriela Porto Santos Almeida | |
Author | Oliveira, Rodrigo Cunha | |
Author | Souza, Juliana Sacramento Mota de | |
Author | Giovanetti, Marta | |
Author | Guimarães, Monick Lindenmeyer | |
Author | Brites, Carlos | |
Author | Cunha, Joana Paixão Monteiro | |
Access date | 2023-01-26T17:29:09Z | |
Available date | 2023-01-26T17:29:09Z | |
Document date | 2022 | |
Citation | SILVA, Gabriela Porto Santos Almeida et al. Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 117, e220109, p. 1 - 7, 2022. | en_US |
ISSN | 0074-0206 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/56641 | |
Language | eng | en_US |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | en_US |
Rights | open access | |
Subject in Portuguese | HIV | en_US |
Subject in Portuguese | F1 sub-subtipo | en_US |
Subject in Portuguese | Filodinâmica | en_US |
Subject in Portuguese | Recombinantes | en_US |
Subject in Portuguese | BF1 | en_US |
Title | Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective | en_US |
Type | Article | |
DOI | 10.1590/0074-02760220109 | |
Abstract | Europe, and South America. In Brazil, this sub-subtype co-circulates with subtypes B and C and several recombinant forms,
mainly BF1 variants.
OBJECTIVES This study aimed to reconstruct the dynamic history of HIV-1 F1 in Brazil.
METHODS HIV-1 near full-length genome and pol gene nucleotide sequences available in public databases were assembled in
two datasets (POL671 and NFLG53) to cover the largest number of F1 sub-subtype sequences. Phylodynamic and temporal
analyses were performed.
FINDINGS Two main strains of the F1 sub-subtype are circulating worldwide. The first (F1.I) was found among Brazilian samples
(75%) and the second (F1.II) among Romanian (62%) and other European and African isolates. The F1 subtype epidemic in
Brazil originated from a single entry into the country around 1970. This ancestral sample is related to samples isolated in
European countries (France, Finland, and Belgium), which are possibly of African origin. Moreover, further migration (1998
CI: 1994-2003) of strains from Brazil to Europe (Spain and the UK) was observed. Interestingly, all different recombinant BF
patterns found, even those from outside Brazil, present the same F1 lineage (F1.I) as an ancestor, which could be related to the
acquisition of adaptive advantages for the recombinant progenies.
MAIN CONCLUSIONS These findings are important for the understanding of the origin and dynamics of the F1 sub-subtype and
a consequent better and greater understanding of the HIV-1 F1 and BF epidemic that still spreads from Brazil to other countries. | en_US |
Affilliation | Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz . Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil. | en_US |
Subject | HIV | en_US |
Subject | F1 sub-subtype | en_US |
Subject | Phylodynamic | en_US |
Subject | Recombinants | en_US |
Subject | BF1 | en_US |