| Author | Andrade, Zilton de Araújo | |
| Author | Silva, Luciana Menezes da | |
| Author | Souza, Márcia Maria de | |
| Author | Sadigursky, Moysés | |
| Author | Barbosa Junior, Aryon de Almeida | |
| Author | Oliveira, Irismar Reis de | |
| Access date | 2012-10-15T19:33:00Z | |
| Available date | 2012-10-15T19:33:00Z | |
| Document date | 1998 | |
| Citation | ANDRADE, Z.A. et al. Role of the spleen on the pathogenesis of schistosomal periportal (pipestem) fibrosis of the liver: an experimental approach. American Journal of Tropical Medicine and Hygiene, v. 59, n. 4, p. 557-62, oct. 1998. | pt_BR |
| ISSN | 0002-9637 | |
| URI | https://www.arca.fiocruz.br/handle/icict/5667 | |
| Language | eng | pt_BR |
| Rights | open access | |
| Title | Role of the spleen on the pathogenesis of schistosomal periportal (pipestem) fibrosis of the liver: an experimental approach. | pt_BR |
| Type | Article | pt_BR |
| Abstract | Splenectomized and sham-operated mice with chronic Schistosoma mansoni infection were compared for the development of periportal fibrosis (pipestem fibrosis). Although this lesion appeared less frequently in splenectomized mice, it also developed in the absence of the spleen. The time of splenectomy, spleen weight, presence of anti-idiotypic antibodies, the number of eggs in the liver, and the type and size of periovular granulomas in the liver as evaluated by computerized morphometry did not show statistically significant differences between the two groups. It is concluded that the role of the spleen in the development of pipestem fibrosis seems ancillary and that multifactorial influences, including worm burden, hepatic vascular adjustment, and factors associated with the biology of extracellular matrix of the liver, probably play a more significant role. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| DeCS | Cirrose Hepática Experimental/etiologia | pt_BR |
| DeCS | Esquistossomose mansoni/complicações | pt_BR |
| DeCS | Baço/fisiologia | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Camundongos | pt_BR |
| DeCS | Baço/patologia | pt_BR |
| DeCS | Esplenectomia | pt_BR |
