Author | Medeiros, Thalia | |
Author | Guimarães, Gabriel Macedo Costa | |
Author | Carvalho, Fabiana Rabe | |
Author | Alves, Lilian Santos | |
Author | Faustino, Renan | |
Author | Azevedo, Ana Carolina Campi | |
Author | Pascoal, Vanessa Peruhype Magalhães | |
Author | Carvalho, Andréa Teixeira de | |
Author | Gomes, Matheus de Souza | |
Author | Amaral, Laurence Rodrigues do | |
Author | Martins Filho, Olindo Assis | |
Author | Lugon, Jocemir Ronaldo | |
Author | Almeida, Jorge Reis | |
Author | Silva, Andrea Alice | |
Access date | 2023-01-30T17:44:00Z | |
Available date | 2023-01-30T17:44:00Z | |
Document date | 2022 | |
Citation | MEDEIROS, Thalia et al. Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators. Cytokine, v. 157, 155974, 2022. doi: 10.1016/j.cyto.2022.155974. | en_US |
ISSN | 1043-4666 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/56769 | |
Language | eng | en_US |
Publisher | Elsevier Science Ltd. | en_US |
Rights | open access | en_US |
Title | Acute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators | en_US |
Type | Article | en_US |
Abstract | Background: Severe cases of coronavirus disease 2019 (COVID-19) have increased risk for acute kidney injury (AKI). The exacerbation of the immune response seems to contribute to AKI development, but the immunopathological process is not completely understood.
Objectives: To analyze levels of circulant immune mediators in COVID-19 patients evolving with or without AKI. We have also investigated possible associations of these mediators with viral load and clinical outcomes.
Methods: This is a longitudinal study performed with hospitalized patients with moderate to severe COVID-19. Serum levels of 27 immune mediators were measured by a multiplex immunoassay. Data were analyzed at two timepoints during the follow-up: within the first 13 days of the disease onset (early sample) and from the 14th day to death or hospital discharge (follow-up sample).
Results: We studied 82 COVID-19 patients (59.5 ± 17.5 years, 54.9% male). Of these, 34 (41.5%) developed AKI. These patients presented higher SARS-CoV-2 viral load (P = 0.03), higher frequency of diabetes (P = 0.01) and death (P = 0.0004). Overall, AKI patients presented significantly higher and sustained levels (P < 0.05) of CCL-2, CCL-3, CCL-4, CXCL-8, CXCL-10, IFN-γ, IL-2, IL-6, TNF-α, IL-1Ra, IL-10 and VEGF. Importantly, higher levels of CCL-2, CXCL-10, IL-2, TNF-α, IL-10, FGFb, and VEGF were observed in AKI patients independently of death. ROC curves demonstrated that early alterations in CCL-2, CXCL-8, CXCL-10, IFN-γ, IL-6, IL-1Ra and IL-10 show a good predictive value regarding AKI development. Lastly, immune mediators were significantly associated with each other and with SARS-CoV-2 viral load in AKI patients.
Conclusions: COVID-19 associated AKI is accompanied by substantial alterations in circulant levels of immune mediators, which could significantly contribute to the establishment of kidney injury. | en_US |
Affilliation | Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil/ Department of Pathology. Faculty of Medicine. Universidade Federal Fluminense. Niterói, RJ, Brazil. | en_US |
Affilliation | Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil | en_US |
Affilliation | Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil | en_US |
Affilliation | Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil | en_US |
Affilliation | Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, Minas Gerais, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, Minas Gerais, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, Minas Gerais, Brazil. | en_US |
Affilliation | Laboratory of Bioinformatics and Molecular Analysis. Federal University of Uberlandia. Patos de Minas, MG, Brazil. | en_US |
Affilliation | Laboratory of Bioinformatics and Molecular Analysis. Federal University of Uberlandia. Patos de Minas, MG, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, Minas Gerais, Brazil. | en_US |
Affilliation | Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil/Department of Clinical Medicine – Nephrology. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil. | en_US |
Affilliation | Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil | en_US |
Affilliation | Multiuser Laboratory for Research Support in Nephrology and Medical Sciences. Hospital Universitario Antonio Pedro. Faculty of Medicine. Universidade Federal Fluminense. Niteroi, RJ, Brazil/ Department of Pathology. Faculty of Medicine. Universidade Federal Fluminense. Niterói, RJ, Brazil. | en_US |
Subject | Acute kidney injury | en_US |
Subject | COVID-19 | en_US |
Subject | Cytokines | en_US |
Subject | Immune mediators | en_US |