| Author | Dias, Michelle Hallais França | |
| Author | Guimarães, Luiz Felipe Ferreira | |
| Author | Barcelos, Matheus Gomes | |
| Author | Moreira, Eduardo Utsch Madureira | |
| Author | Nascimento, Maria Fernanda Alves do | |
| Author | Souza, Taís Nobrega de | |
| Author | Pires, Camilla Valente | |
| Author | Monteiro, Talita A. F. | |
| Author | Middeldorp, Jaap M. | |
| Author | Soares, Irene S. | |
| Author | Fontes, Cor Jesus Fernandes | |
| Author | Ntumngia, Francis B. | |
| Author | Adams, John H. | |
| Author | Kano, Flora Satiko | |
| Author | Carvalho, Luzia Helena | |
| Access date | 2023-02-01T14:24:42Z | |
| Available date | 2023-02-01T14:24:42Z | |
| Document date | 2022 | |
| Citation | DIAS, Michelle Hallais França et al. Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response. PLoS Neglected Tropical Diseases, v. 16, n. 8, p. 1-22, Aug. 2022. | en_US |
| ISSN | 1935-2735 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56810 | |
| Language | eng | en_US |
| Publisher | Public Library of Science | en_US |
| Rights | open access | en_US |
| Title | Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response | en_US |
| Type | Article | en_US |
| DOI | 10.1371/journal.pntd.0010305 | |
| Abstract | Background: The simultaneous infection of Plasmodium falciparum and Epstein-Barr virus (EBV) could promote the development of the aggressive endemic Burkitt's Lymphoma (eBL) in children living in P. falciparum holoendemic areas. While it is well-established that eBL is not related to other human malaria parasites, the impact of EBV infection on the generation of human malaria immunity remains largely unexplored. Considering that this highly prevalent herpesvirus establishes a lifelong persistent infection on B-cells with possible influence on malaria immunity, we hypothesized that EBV co-infection could have impact on the naturally acquired antibody responses to P. vivax, the most widespread human malaria parasite. Methodology/principal findings: The study design involved three cross-sectional surveys at six-month intervals (baseline, 6 and 12 months) among long-term P. vivax exposed individuals living in the Amazon rainforest. The approach focused on a group of malaria-exposed individuals whose EBV-DNA (amplification of balf-5 gene) was persistently detected in the peripheral blood (PersVDNA, n = 27), and an age-matched malaria-exposed group whose EBV-DNA could never be detected during the follow-up (NegVDNA, n = 29). During the follow-up period, the serological detection of EBV antibodies to lytic/ latent viral antigens showed that IgG antibodies to viral capsid antigen (VCA-p18) were significantly different between groups (PersVDNA > NegVDNA). A panel of blood-stage P. vivax antigens covering a wide range of immunogenicity confirmed that in general PersVDNA group showed low levels of antibodies as compared with NegVDNA. Interestingly, more significant differences were observed to a novel DBPII immunogen, named DEKnull-2, which has been associated with long-term neutralizing antibody response. Differences between groups were less pronounced with blood-stage antigens (such as MSP1-19) whose levels can fluctuate according to malaria transmission. Conclusions/significance: In a proof-of-concept study we provide evidence that a persistent detection of EBV-DNA in peripheral blood of adults in a P. vivax semi-immune population may impact the long-term immune response to major malaria vaccine candidates. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Center for Global Health and Infectious Diseases Research. Department of Global Health. College of Public Health. University of South Florida. Tampa, FL, USA. | en_US |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brazil. | en_US |
| Affilliation | Department of Pathology. Free University Medical Center. Amsterdam, The Netherlands. | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade Federal de Mato Grosso. Faculdade de Medicina. Julio Müller School Hospital. Cuiabá, MT, Brazil. | en_US |
| Affilliation | Center for Global Health and Infectious Diseases Research. Department of Global Health. College of Public Health. University of South Florida. Tampa, FL, USA. | en_US |
| Affilliation | Center for Global Health and Infectious Diseases Research. Department of Global Health. College of Public Health. University of South Florida. Tampa, FL, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Subject | Epstein-Barr virus (EBV) | |
| Subject | Co-infection | |
| Subject | Plasmodium vivax | |
| Subject | Plasmodium falciparum | |
| Subject | Aggressive endemic Burkitt’s Lymphoma (eBL) | |
