Author | DeBarry, Jeremy D. | |
Author | Nural, Mustafa V. | |
Author | Pakala, Suman B. | |
Author | Nayak, Vishal | |
Author | Warrenfeltz, Susanne | |
Author | Humphrey, Jay | |
Author | Lapp, Stacey A. | |
Author | Cabrera-Mora, Monica | |
Author | Brito, Cristiana Ferreira Alves de | |
Author | Jiang, Jianlin | |
Author | Saney, Celia L. | |
Author | Hankus, Allison | |
Author | Stealey, Hannah M. | |
Author | DeBarry, Megan B. | |
Author | Lackman, Nicolas | |
Author | Legall, Noah | |
Author | Lee, Kevin | |
Author | Tang, Yan | |
Author | Gupta, Anuj | |
Author | Trippe, Elizabeth D. | |
Author | Bridger, Robert R. | |
Author | Weatherly, Daniel Brent | |
Author | Peterson, Mariko S. | |
Author | Jiang, Xuntian | |
Author | Tran, ViLinh | |
Author | Uppal, Karan | |
Author | Fonseca, Luis L. | |
Author | Joyner, Chester J. | |
Author | Karpuzoglu, Ebru | |
Author | Cordy, Regina J. | |
Author | Meyer, Esmeralda V. S. | |
Author | Wells, Lance L. | |
Author | Ory, Daniel S. | |
Author | Lee, F. Eun-Hyung | |
Author | Tirouvanziam, Rabindra | |
Author | Gutiérrez, Juan B. | |
Author | Ibegbu, Chris | |
Author | Lamb, Tracey J. | |
Author | Pohl, Jan | |
Author | Pruett, Sarah T. | |
Author | Jones, Dean P. | |
Author | Styczynski, Mark P. | |
Author | Voit, Eberhard O. | |
Author | Moreno, Alberto | |
Author | Galinski, Mary R. | |
Access date | 2023-02-07T16:59:56Z | |
Available date | 2023-02-07T16:59:56Z | |
Document date | 2022 | |
Citation | DEBARRY Jeremy D. et al. MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques. Sci Data, v. 9, n. 1, 722, 2022. doi: 10.1038/s41597-022-01755-y. | en_US |
ISSN | 2052-4463 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/56929 | |
Language | eng | en_US |
Publisher | Nature Publishing Group | en_US |
Rights | open access | en_US |
Title | MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques | en_US |
Type | Article | en_US |
Abstract | Plasmodium cynomolgi causes zoonotic malarial infections in Southeast Asia and this parasite species is important as a model for Plasmodium vivax and Plasmodium ovale. Each of these species produces hypnozoites in the liver, which can cause relapsing infections in the blood. Here we present methods and data generated from iterative longitudinal systems biology infection experiments designed and performed by the Malaria Host-Pathogen Interaction Center (MaHPIC) to delve deeper into the biology, pathogenesis, and immune responses of P. cynomolgi in the Macaca mulatta host. Infections were initiated by sporozoite inoculation. Blood and bone marrow samples were collected at defined timepoints for biological and computational experiments and integrative analyses revolving around primary illness, relapse illness, and subsequent disease and immune response patterns. Parasitological, clinical, haematological, immune response, and -omic datasets (transcriptomics, proteomics, metabolomics, and lipidomics) including metadata and computational results have been deposited in public repositories. The scope and depth of these datasets are unprecedented in studies of malaria, and they are projected to be a F.A.I.R., reliable data resource for decades. | en_US |
Affilliation | Institute of Bioinformatics. University of Georgia.Athens, GA, USA | en_US |
Affilliation | Institute of Bioinformatics. University of Georgia, Athens, GA, USA | en_US |
Affilliation | Department of Medicine. Vanderbilt University Medical Center. Nashville, TN, USA/ Institute of Bioinformatics. University of Georgia, Athens, GA, USA | en_US |
Affilliation | Cancer Data Science Initiatives. Frederick National Laboratory for Cancer Research. Frederick, MD, USA/Institute of Bioinformatics. University of Georgia, Athens, GA, USA | en_US |
Affilliation | Center for Tropical and Emerging Global Diseases. University of Georgia. Athens, GA, USA | en_US |
Affilliation | Center for Tropical and Emerging Global Diseases. University of Georgia. Athens, GA, USA/Institute of Bioinformatics, University of Georgia. Athens, GA, USA | en_US |
Affilliation | Department of Pediatrics. Emory University School of Medicine. Atlanta, GA, USA/Emory Vaccine Center. Yerkes/Emory National Primate Research Center. Emory University, Atlanta, GA, USA | en_US |
Affilliation | Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine. Department of Medicine. Emory University School of Medicine. Atlanta, GA, USA/Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil/Emory Vaccine Center. Yerkes. Atlanta, GA, USA/Emory National Primate Research Center. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Present address: Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA/Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Senior Public Health Informaticist. MITRE Corp, Atlanta, GA, USA/ Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Department of Biomedical Engineering. University of Texas at Austin. Austin, TX, USA/Institute of Bioinformatics. University of Georgia. Athens, GA, USA | en_US |
Affilliation | Institute of Bioinformatics, University of Georgia. Athens, GA, USA | en_US |
Affilliation | Institute of Bioinformatics, University of Georgia, Athens, GA, USA | en_US |
Affilliation | Interdisciplinary Disease Ecology Across Scales Research Traineeship Program. Institute of Bioinformatics. Center for the Ecology of Infectious Diseases. University of Georgia. Athens, GA, USA/Institute of Bioinformatics. University of Georgia. Athens, GA, USA | en_US |
Affilliation | Center for Integrative Genomics. School of Biology. Georgia Institute of Technology. Atlanta, GA, USA | en_US |
Affilliation | Department of Medicine. Brigham and Women’s Hospital. Harvard Medical School. Boston, MA, USA/School of Chemical & Biomolecular Engineering. Georgia Institute of Technology. Atlanta, GA, USA | en_US |
Affilliation | The Wallace H. Coulter Department of Biomedical Engineering. Georgia Institute of Technology and Emory University. Atlanta, GA, USA | en_US |
Affilliation | Federal Drug Administration. Silver Spring, MD, USA/Institute of Bioinformatics. University of Georgia. Athens.GA, USA | en_US |
Affilliation | Complex Carbohydrate Research Center. Department of Biochemistry. University of Georgia. Athens, GA, USA | en_US |
Affilliation | Complex Carbohydrate Research Center. Department of Biochemistry. University of Georgia, Athens. GA, USA | en_US |
Affilliation | Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA | en_US |
Affilliation | Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA | en_US |
Affilliation | Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA | en_US |
Affilliation | Division of Endocrinology, Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA/The Wallace H. Coulter Department of Biomedical Engineering. Georgia Institute of Technology and Emory University. Atlanta, GA, USA | en_US |
Affilliation | Center for Tropical and Emerging Global Disease. University of Georgia. Athens, GA, USA/ Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Department of Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA, USA/ Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Department of Biology. Wake Forest University. Winston Salem, NC, USA/Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Institutional Animal Care and Use Committee, Research Compliance and Research Integrity Office, Emory University, Atlanta, GA, USA// Emory Vaccine Center. Yerkes. Atlanta, GA, USA /Emory National Primate Research Center. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Complex Carbohydrate Research Center. Department of Biochemistry. University of Georgia, Athens. GA, USA | en_US |
Affilliation | Casma Therapeutics, Cambridge, MA, USA/Division of Endocrinology. Metabolism & Lipid Research. Washington University School of Medicine. St. Louis, MO, USA | en_US |
Affilliation | Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. Lowance Center for Human Immunology. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Department of Pediatrics. Emory University School of Medicine. Atlanta, GA, USA | en_US |
Affilliation | University of Texas at San Antonio. San Antonio, TX, USA/Institute of Bioinformatics. University of Georgia. Athens, GA, USA/Department of Mathematics, Institute of Bioinformatics, University of Georgia, Athens, GA, USA | en_US |
Affilliation | Emory Vaccine Center. Atlanta, GA, USA/Emory National Primate Research Center. Emory University. Atlanta, GA, USA | en_US |
Affilliation | Department of Pathology University of Utah Salt Lake City, UT, USA/Department of Pediatrics Emory University School of Medicine Atlanta, GA, USA/Division of Infectious Diseases Department of Medicine Emory University School of Medicine Atlanta, GA, USA/Yerkes/Emory National Primate Research Center Emory University Atlanta, GA, USA | en_US |
Affilliation | Biotechnology Core Facility Branch. Centers for Disease Control and Prevention. Atlanta, GA, USA | en_US |
Affilliation | University of Tennessee. Knoxville, TN, USA/Yerkes/Emory National Primate Research Center. Emory University. Atlanta, GA USA | en_US |
Affilliation | Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine. Department of Medicine. Emory University School of Medicine. Atlanta, GA, USA | en_US |
Affilliation | School of Chemical & Biomolecular Engineering. Georgia Institute of Technology. Atlanta, GA, USA | en_US |
Affilliation | The Wallace H. Coulter Department of Biomedical Engineering. Georgia Institute of Technology and Emory University. Atlanta, GA, USA | en_US |
Affilliation | Division of Infectious Diseases. Department of Medicine. Emory University. School of Medicine. Atlanta, GA, USA | en_US |
Affilliation | Emory Vaccine Center, Yerkes/Emory National Primate Research Center. Emory University. Atlanta, GA, USA/Division of Infectious Diseases. Department of Medicine. Emory University School of Medicine. Atlanta, GA, USA/Institute of Bioinformatics. University of Georgia. Athens, USA/Center for Tropical and Emerging Global Diseases. University of Georgia. Athens. GA, USA/Department of Genetics. University of Georgia. Athens, GA, USA | en_US |