| Author | Sabatke, Bruna | |
| Author | Chaves, Pedro Felipe P. | |
| Author | Cordeiro, Lucimara M. C. | |
| Author | Ramirez, Marcel Ivan | |
| Access date | 2023-02-10T14:45:20Z | |
| Available date | 2023-02-10T14:45:20Z | |
| Document date | 2022 | |
| Citation | SABATKE, Bruna et al. Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis. Life., v. 12, n. 2091, p. 1–9, 2022. | en_US |
| ISSN | 2075-1729 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57002 | |
| Language | por | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Title | Synergistic effect of polysaccharides from chamomile tea with nitazoxanide increases treatment efficacy against Giardia intestinalis | en_US |
| Type | Article | en_US |
| DOI | 10.3390/life12122091 | |
| Abstract | Giardia intestinalis (syn. G. lamblia, G. duodenalis) is a protozoa parasite that produces one of the most frequent waterborne causes of diarrhea worldwide. This protozoan infects most mammals, including humans, and colonizes the small intestine, adhering to intestinal cells. The mechanism by which G. intestinalis causes diarrhea is multifactorial, causing intestinal malabsorption. The treatment of giardiasis uses chemotherapeutic drugs such as nitroimidazoles, furazolidone, paromomycin, and benzimidazole compounds. However, they are toxic, refractory, and may generate resistance. To increase efficacy, a current treatment strategy is to combine these drugs with other compounds, suchas polysaccharides. Several studies have shown that polysaccharides have gastroprotective effects. Polysaccharides are high-molecular weight polymers, and they differ in structure and functions, being widely extracted from vegetables and fruits. In the present study, we show that polysaccharides found in chamomile tea (called MRW), in contact with antiparasitic agents, potentially inhibit the adhesion of parasites to intestinal cells. Moreover, at 500 µg/mL, they act synergistically with nitazoxanide (NTZ), increasing its effectiveness and decreasing the drug dose needed for giardiasis treatment. | en_US |
| Affilliation | Universidade Federal do Paraná. Programa de Pós-Graduação em Microbiologia, Parasitologia e Patologia. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Molecular e Sistêmica de Tripanossomatídeos. EVAHPI – Extracellular Vesicles and Host-Parasite Interactions Research Group. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Molecular e Sistêmica de Tripanossomatídeos. EVAHPI – Extracellular Vesicles and Host-Parasite Interactions Research Group. Curitiba, PR, Brasil. | en_US |
| Subject | Chamomile | en_US |
| Subject | Polysaccharides | en_US |
| Subject | Giardia intestinalis | en_US |
| Subject | Antiparasitic Agents | en_US |
| Subject | Complementary Therapies | en_US |
| Subject | Synergism | en_US |
| Subject in Spanish | Manzanilla | en_US |
| Subject in Spanish | Polisacáridos | en_US |
| Subject in Spanish | Giardiasis | en_US |
| Subject in Spanish | Antiparasitarios | en_US |
| Subject in Spanish | Terapias Complementarias | en_US |
| Subject in French | Camomille | en_US |
| Subject in French | Polyosides | en_US |
| Subject in French | Antiparasitaires | en_US |
| Subject in French | Thérapies complémentaires | en_US |
| Subject in French | Synergie | en_US |
| DeCS | Camomila | en_US |
| DeCS | Polissacarídeos | en_US |
| DeCS | Giardíase | en_US |
| DeCS | Antiparasitários | en_US |
| DeCS | Terapias Complementares | en_US |
| DeCS | Sinergismo de Substâncias Bioativas | en_US |
