| Author | Sousa Junior, Ivanildo Pedro | |
| Author | Vieira, Tuane Cristine Ramos Gonçalves | |
| Access date | 2023-02-11T13:37:15Z | |
| Available date | 2023-02-11T13:37:15Z | |
| Document date | 2023 | |
| Citation | SOUSA JUNIOR, Ivanildo Pedro; VIEIRA, Tuane Cristine Ramos Gonçalves. Enterovirus infection and its relationship with neurodegenerative diseases. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 118, e220252, p. 1-7, 2023. | en_US |
| ISSN | 0074-0206 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57021 | |
| Language | eng | en_US |
| Publisher | Fiocruz/IOC | en_US |
| Rights | open access | |
| Subject in Portuguese | Enterovirus | en_US |
| Subject in Portuguese | Doenças neurodegenerativas | en_US |
| Subject in Portuguese | Esclerose Lateral Amiotrófica | en_US |
| Subject in Portuguese | Mal de Parkinson | en_US |
| Subject in Portuguese | Doença de Alzheimer | en_US |
| Title | Enterovirus infection and its relationship with neurodegenerative diseases | en_US |
| Type | Article | |
| DOI | 10.1590/0074-02760220252 | |
| Abstract | Neurodegenerative diseases (NDs) are increasingly common, especially in populations with higher life expectancies. They are associated mainly with protein metabolism and structure changes, leading to neuronal cell death. Viral infections affect these cellular processes and may be involved in the etiology of several neurological illnesses, particularly NDs. Enteroviruses (EVs) frequently infect the central nervous system (CNS), causing neurological disease. Inflammation, disruption of the host autophagy machinery, and deregulation and accumulation/misfolding of proteins are the main alterations observed after infection by an EV. In this perspective, we discuss the most recent findings on the subject, examining the possible role of EVs in the development of NDs, and shedding light on the putative role played by these viruses in developing NDs. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagem. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Enterovirus | en_US |
| Subject | Neurodegenerative diseases | en_US |
| Subject | Amyotrophic lateral sclerosis | en_US |
| Subject | Parkinson’s disease | en_US |
| Subject | Alzheimer’s disease | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
