| Author | Lapidus, Sarah | |
| Author | Liu, Feimei | |
| Author | Massana, Arnau Casanovas | |
| Author | Dai, Yile | |
| Author | Huck, John D. | |
| Author | Lucas, Carolina | |
| Author | Klein, Jon | |
| Author | Filler, Renata B. | |
| Author | Strine, Madison S. | |
| Author | Sy, Mouhamad | |
| Author | Deme, Awa B. | |
| Author | Badiane, Aida S. | |
| Author | Dieye, Baba | |
| Author | Ndiaye, Ibrahima Mbaye | |
| Author | Diedhiou, Younous | |
| Author | Mbaye, Amadou Moctar | |
| Author | Diagne, Cheikh Tidiane | |
| Author | Womas, Ines Vigan | |
| Author | Mbengue, Alassane | |
| Author | Sadio, Bacary D. | |
| Author | Diagne, Moussa M. | |
| Author | Moore, Adam J. | |
| Author | Mangou, Khadidiatou | |
| Author | Diallo, Fatoumata | |
| Author | Sene, Seynabou D. | |
| Author | Pouye, Mariama N. | |
| Author | Faye, Rokhaya | |
| Author | Diouf, Babacar | |
| Author | Nery Jr, Nivison | |
| Author | Costa, Federico | |
| Author | Reis, Mitermayer | |
| Author | Muenker, M. Catherine | |
| Author | Hodson, Daniel Z. | |
| Author | Mbarga, Yannick | |
| Author | Katz, Ben Z. | |
| Author | Andrews, Jason R. | |
| Author | Campbell, Melissa | |
| Author | Srivathsan, Ariktha | |
| Author | Kamath, Kathy | |
| Author | Jones, Elisabeth Baum | |
| Author | Faye, Ousmane | |
| Author | Sall, Amadou Alpha | |
| Author | Velez, Juan Carlos Quintero | |
| Author | Cappello, Michael | |
| Author | Wilson, Michael | |
| Author | Mamoun, Choukri Ben | |
| Author | Tedder, Richard | |
| Author | McClure, Myra | |
| Author | Cherepanov, Peter | |
| Author | Somé, Fabrice A. | |
| Author | Dabiré, Roch K. | |
| Author | Moukoko, Carole Else Eboumbou | |
| Author | Ouédraogo, Jean Bosco | |
| Author | Yap, Boum II | |
| Author | Shon, John | |
| Author | Ndiaye, Daouda | |
| Author | Wisnewski, Adam | |
| Author | Parikh, Sunil | |
| Author | Iwasaki, Akiko | |
| Author | Wilen, Craig B. | |
| Author | Ko, Albert I. | |
| Author | Ring, Aaron M. | |
| Author | Bei, Amy K. | |
| Access date | 2023-02-13T15:12:21Z | |
| Available date | 2023-02-13T15:12:21Z | |
| Document date | 2022 | |
| Citation | LAPIDUS, Sarah et al. Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein. Scientific Reports, v. 12, p. 1-16, 2022. | en_US |
| ISSN | 2045-2322 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57035 | |
| Sponsorship | Fogarty International Center of the NIH.
National Institute of Allergy and Infectious Diseases of the NIH.
Yale School of Public Health Start-up funds.
G4 group.
Institut Pasteur de Paris e Agence Universitaire de la Francophonie.
Burroughs Wellcome Fund Career Award for Medical Scientists.
Ludwig Family Foundation.
Mathers Charitable Foundation.
Emergent Ventures fast Grant.
National Center for Advancing Translational Science (NCATS). | en_US |
| Language | eng | en_US |
| Publisher | Nature Research | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Plasmodium | en_US |
| Subject in Portuguese | Infecção | en_US |
| Subject in Portuguese | Anticorpos | en_US |
| Subject in Portuguese | Epítopos de carboidratos | en_US |
| Subject in Portuguese | SARS-CoV-2 | en_US |
| Subject in Portuguese | Proteínas | en_US |
| Title | Plasmodium infection is associated with cross‑reactive antibodies to carbohydrate epitopes on the SARS‑CoV‑2 Spike protein | en_US |
| Type | Article | en_US |
| DOI | 10.1038/s41598-022-26709-7 | |
| Abstract | Sero-surveillance can monitor and project disease burden and risk. However, SARS-CoV-2 antibody test results can produce false positive results, limiting their efficacy as a sero-surveillance tool. False positive SARS-CoV-2 antibody results are associated with malaria exposure, and understanding this association is essential to interpret sero-surveillance results from malaria-endemic countries. Here, pre-pandemic samples from eight malaria endemic and non-endemic countries and four continents were tested by ELISA to measure SARS-CoV-2 Spike S1 subunit reactivity. Individuals with acute malaria infection generated substantial SARS-CoV-2 reactivity. Cross-reactivity was not associated with reactivity to other human coronaviruses or other SARS-CoV-2 proteins, as measured by peptide and protein arrays. ELISAs with deglycosylated and desialated Spike S1 subunits revealed that cross-reactive antibodies target sialic acid on N-linked glycans of the Spike protein. The functional activity of cross-reactive antibodies measured by neutralization assays showed that cross-reactive antibodies did not neutralize SARS-CoV-2 in vitro. Since routine use of glycosylated or sialated assays could result in false positive SARS-CoV-2 antibody results in malaria endemic regions, which could overestimate exposure and population-level immunity, we explored methods to increase specificity by reducing cross-reactivity. Overestimating population-level exposure to SARS-CoV-2 could lead to underestimates of risk of continued COVID-19 transmission in sub-Saharan Africa. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA. | en_US |
| Affilliation | Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA. | en_US |
| Affilliation | Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA / Department of Laboratory Medicine. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA / Department of Laboratory Medicine. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal. | en_US |
| Affilliation | Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal. | en_US |
| Affilliation | Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal. | en_US |
| Affilliation | Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal. | en_US |
| Affilliation | Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal. | en_US |
| Affilliation | Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal. | en_US |
| Affilliation | DiaTROPIX Rapid Diagnostic Tests Facility. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | Pôle Virologie. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA. | en_US |
| Affilliation | G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Department of Internal Medicine, Yale Occupational and Environmental Medicine Program. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA. | en_US |
| Affilliation | Douala Military Hospital. Douala, Cameroon. | en_US |
| Affilliation | Division of Infectious Diseases. Department of Pediatrics. Northwestern University Feinberg School of Medicine. Ann & Robert H. Lurie Children’s Hospital of Chicago. Chicago, USA. | en_US |
| Affilliation | Division of Infectious Diseases and Geographic Medicine. School of Medicine. Stanford University. Stanford, CA, USA. | en_US |
| Affilliation | Yale Center for Clinical Investigation. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA. | en_US |
| Affilliation | Serimmune. Inc. Goleta, CA, USA. | en_US |
| Affilliation | Serimmune. Inc. Goleta, CA, USA. | en_US |
| Affilliation | Pôle Virologie. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | Pôle Virologie. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Grupo de Investigación Ciencias Veterinarias Centauro. University of Antioquia. Medellín, Colombia /Grupo de Investigación Microbiología Básica y aplicada. University of Antioquia. Medellín, Colombia. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Department of Pediatrics. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Parasitology. Noguchi Memorial Institute for Medical Research. University of Ghana. Accra, Ghana. | en_US |
| Affilliation | Department of Internal Medicine. Section of Infectious Diseases. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Infectious Disease. Imperial College London. St Mary’s Campus. London, UK. / South London Specialist Virology Centre. Kings College Hospital NHS Foundation Trust. London, UK. | en_US |
| Affilliation | Department of Infectious Disease. Imperial College London. St Mary’s Campus. London, UK. | en_US |
| Affilliation | Department of Infectious Disease. Imperial College London. St Mary’s Campus. London, UK / Chromatin Structure and Mobile DNA Laboratory. The Francis Crick Institute. London, UK /Crick COVID19 Consortium. Francis Crick Institute. London, UK. | en_US |
| Affilliation | Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz. Bobo Dioulasso. Burkina Faso. | en_US |
| Affilliation | Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz. Bobo Dioulasso. Burkina Faso. | en_US |
| Affilliation | Department of Biological Sciences. Faculty of Medicine and Pharmaceutical Sciences. University of Douala. Douala, BP, Cameroon / Malaria Research Unit. Center Pasteur Cameroon. Yaoundé, Cameroon. | en_US |
| Affilliation | Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz. Bobo Dioulasso. Burkina Faso. | en_US |
| Affilliation | Médecins Sans Frontières. University of Yaoundé and Epicentre. Yaoundé, Cameroon. | en_US |
| Affilliation | Serimmune. Inc. Goleta, CA, USA. | en_US |
| Affilliation | Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal. | en_US |
| Affilliation | Department of Internal Medicine, Yale Occupational and Environmental Medicine Program. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA / Howard Hughes Medical Institute. Chevy Chase, MD, USA. | en_US |
| Affilliation | Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Department of Immunobiology. Yale School of Medicine. New Haven, CT, USA. | en_US |
| Affilliation | Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Laboratory of Parasitology and Mycology. Aristide le Dantec Hospital. Cheikh Anta Diop University. Dakar, Senegal / G4 Malaria Experimental Genetic Approaches and Vaccines. Pôle Immunophysiopathologie et Maladies Infectieuses. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Subject | Plasmodium | en_US |
| Subject | Infection | en_US |
| Subject | Antibodies | en_US |
| Subject | carbohydrate epitopes | en_US |
| Subject | SARS‑CoV‑2 | en_US |
| Subject | Protein | en_US |
| DeCS | Plasmodium | en_US |
| DeCS | Infecções | en_US |
| DeCS | Anticorpos | en_US |
| DeCS | Epítopos | en_US |
| DeCS | Carboidratos | en_US |
| DeCS | SARS-CoV-2 | en_US |
| DeCS | Proteínas | en_US |
