| Author | Serra, Fabiana C. | |
| Author | Hadad, David | |
| Author | Orofino, Renata L. | |
| Author | Marinho, Flavia | |
| Author | Lourenço, Cristina | |
| Author | Morgado, Mariza | |
| Author | Rolla, Valeria | |
| Access date | 2023-02-24T19:00:28Z | |
| Available date | 2023-02-24T19:00:28Z | |
| Document date | 2007 | |
| Citation | SERRA, Fabiana C. et al. Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro. The Brazilian Journal of Infectious Diseases, v. 11, n. 5, p. 458-461, Oct. 2007. | en_US |
| ISSN | 1413-8670 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57113 | |
| Language | eng | en_US |
| Publisher | Brazilian Society of Infectious Diseases | en_US |
| Rights | open access | |
| Title | Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro | en_US |
| Type | Article | |
| DOI | 10.1590/S1413-86702007000500004 | |
| Abstract | We made a retrospective longitudinal study from January 2000 to January 2003 to examine cases of immune reconstitution syndrome (IRS) and its incidence rate in tuberculosis (TB)-human immunodeficiency virus (HIV) co-infected patients. The incidence rate (IR) was calculated using a Poisson regression. The confidence interval (CI) that was stipulated was 95%. IRS occurred in 10/84 HIV and TB-positive patients; nine of them were on highly active anti-retroviral therapy (HAART) during a mean of 61.7 (±59) days following the introduction of antiretrovirals. Lymph-node enlargement was the sole clinical manifestation. CD4 counts were <100 cells/mm³in 50% of the patients, at the time of TB diagnosis. All but two patients were treated with prednisone, and recovered from TB within a mean of 91 days (±30 days). One relapse of TB was observed, but there were no IRS-related deaths. The incidence rate was higher (IR=11.18; CI, 1.41-88.76) in patients that had superficial lymph node enlargement at the moment of TB diagnosis (not associated with TB), extrapulmonary TB (IR=1.97; CI, 0.44-8.79), were antiretroviral naive (IR=1.85; CI, 0.48-7.16), and CD4 counts <100 cells/mm³ (IR=1.50; CI, 0.40-5.59), although with a wide CI. IRS was frequent in our sample, occurred more frequently in HIV-naive patients with lymph-node enlargement and extrapulmonary TB. No cases of new pulmonary lesions or worsening of pulmonary infiltrates were observed. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Espírito Santo. Center of Infectious Diseases. Vitória, ES, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratory of Immunology in HIV/AIDS. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | AIDS | en_US |
| Subject | Immune reconstitution syndrome | en_US |
| Subject | Tuberculosis | en_US |
| Subject | HAART | en_US |
| Subject | Lymph node enlargement | en_US |
| Subject | Paradoxical reaction | en_US |
| e-ISSN | 1678-4391 | |
