Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5721
Full metadata record
DC FieldValue
dc.contributor.authorSilva, Rosângela Castro
dc.contributor.authorSantiago, Christiane Maria Gaspar
dc.contributor.authorPontes, Albélia Lima
dc.contributor.authorAndrade, Sonia Gumes
dc.date.accessioned2012-10-23T17:50:52Z
dc.date.available2012-10-23T17:50:52Z
dc.date.issued1989
dc.identifier.citationSILVA, R.C. et al. Padrao isoenzimático da cepa Y do Trypanosoma cruzi após quimioterapia especifica. Memórias do Instituto Oswaldo Cruz, v. 84, n. 1, p. 81-6, jan.-mar. 1989.
dc.identifier.issn0074-0276
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/5721
dc.language.isoeng
dc.rightsopen access
dc.titlePadrao isoenzimático da cepa Y do Trypanosoma cruzi após quimioterapia especifica
dc.typeArticle
dc.description.abstractenThe isoenzyme pattern of the Trypanosoma cruzi Y strain recovered from mice inoculated with 15 x 10(4) blood trypomastigotes and previously treated with either Bay 2502 (Nifurtimox) or Ro 7-1051 (Benzonidazol) was analyzed in the following situations: a) strain resistant to Bay 2502 and again treated with the same drug; b) strain resistant to Bay 2502 and treated with Ro 7-1051; c) strain resistant to Ro 7-1051 and treated with that same drug. Although marked drug resistance was noted in all cases, the isoenzyme pattern of the Y strain for GPI, PGM, ALAT and ASAT remained throughout the same. The pattern was similar to that of the Peruvian strain, which also belongs to the same strain Type of the Y strain, but differed from those of the 21 SF (Type II) and Colombian (Type III) strains. Thus, the appearance of drug resistance in T. cruzi strain was not associated with a change in its isoenzymatic pattern.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.subject.enTrypanosoma cruzi
dc.subject.enIsoenzymes
dc.subject.enChemotherapy
dc.subject.enBenzonidazol
dc.subject.enNifurtimox
dc.subject.decsIsoenzimas/análise
dc.subject.decsNifurtimox/uso terapêutico
dc.subject.decsNitrofuranos/uso terapêutico
dc.subject.decsNitroimidazóis/uso terapêutico
dc.subject.decsTripanossomicidas/uso terapêutico
dc.subject.decsTrypanosoma cruzi/efeitos de drogas
dc.subject.decsAnimais
dc.subject.decsDoença de Chagas/quimioterapia
dc.subject.decsEletroforese
dc.subject.decsCamundongos
dc.subject.decsTrypanosoma cruzi/enzimologia
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Silva RC Isoenzymatic pattern of Trypanosoma....pdf289.9 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.