| Author | Oliveira, Thalita Mázala de | |
| Author | Sá, Yago Amigo Pinho Jannini de | |
| Author | Carvalho, Vinicius de Frias | |
| Access date | 2023-03-03T18:42:51Z | |
| Available date | 2023-03-03T18:42:51Z | |
| Document date | 2023 | |
| Citation | OLIVEIRA, Thalita Mázala de; Sá, Yago Amigo Pinho Jannini de; Carvalho, Vinicius de Frias. Impact of gut-peripheral nervous system axis on the development of diabetic neuropathy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 118, e220197, p. 1-10, Feb. 2023. | en_US |
| ISSN | 0074-0206 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57242 | |
| Language | eng | en_US |
| Publisher | Fiocruz/IOC | en_US |
| Rights | open access | |
| Subject in Portuguese | Diabetes | en_US |
| Subject in Portuguese | Disbiose | en_US |
| Subject in Portuguese | Microbiota intestinal | en_US |
| Subject in Portuguese | Inflamação | en_US |
| Subject in Portuguese | Neuropatia | en_US |
| Title | Impact of gut-peripheral nervous system axis on the development of diabetic neuropathy | en_US |
| Type | Article | |
| DOI | 10.1590/0074-02760220197 | |
| Abstract | Diabetes is a chronic metabolic disease caused by a reduction in the production and/or action of insulin, with consequent development of hyperglycemia. Diabetic patients, especially those who develop neuropathy, presented dysbiosis, with an increase in the proportion of pathogenic bacteria and a decrease in the butyrate-producing bacteria. Due to this dysbiosis, diabetic patients presented a weakness of the intestinal permeability barrier and high bacterial product translocation to the bloodstream, in parallel to a high circulating levels of pro-inflammatory cytokines such as TNF-α. In this context, we propose here that dysbiosis-induced increased systemic levels of bacterial products, like lipopolysaccharide (LPS), leads to an increase in the production of pro-inflammatory cytokines, including TNF-α, by Schwann cells and spinal cord of diabetics, being crucial for the development of neuropathy. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Cedars-Sinai Medical Center. Medicine Department. Los Angeles, CA, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, 2023. | en_US |
| Subject | Diabetes | en_US |
| Subject | Dysbiosis | en_US |
| Subject | Gut microbiota | en_US |
| Subject | Inflammation | en_US |
| Subject | Neuropathy | en_US |
