| Author | Santos, Luana Cristina Diniz | |
| Author | Azevedo, Lucas Santos | |
| Author | Siqueira Filho, Ezequias Pessoa de | |
| Author | Castro, Ana Hortência Fonsêca | |
| Author | Lima, Luciana Alves Rodrigues dos Santos | |
| Access date | 2023-03-16T13:26:20Z | |
| Available date | 2023-03-16T13:26:20Z | |
| Document date | 2023 | |
| Citation | SANTOS, Luana Cristina Diniz et al. Chemical characterization, antioxidant activity, and cytotoxicity of fatty acids methyl esters from Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) seeds. Natural Product Research, 2023. doi.org/10.1080/14786419.2023.2179624 | en_US |
| ISSN | 1478-6427 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57400 | |
| Language | eng | en_US |
| Publisher | Taylor and Francis | en_US |
| Rights | open access | en_US |
| Title | Chemical characterization, antioxidant activity, and cytotoxicity of fatty acids methyl esters from Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) seeds | en_US |
| Type | Article | en_US |
| Abstract | Handroanthus impetiginosus, popularly known as “ipê-roxo”, is used in folk medicine to treat skin inflammations, infections, stomach diseases, and cancer. Fatty acid methyl esters (FAMEs) obtained from the esterification reaction of fatty acids (FA) found in the hexane extract (HE) of seeds of H. impetiginosus were identified by gas chromatography-mass spectrometry (GC-MS). The antioxidant and cytotoxic activities of the HE and FAMEs were evaluated. Methyl palmitate, methyl linoleate, methyl oleate, and methyl stearate were the major FAMEs obtained from the HE. The samples, especially the HE, exhibited a significant antioxidant potential analyzed by ferric reducing ability power (FRAP) assay. In the A. salina larvae bioassay, the HE showed no cytotoxic effects, but the FAMEs exhibited a high toxicity. This study reported, for the first time, the antioxidant and cytotoxic activities of the HE and FAMEs obtained from H. impetiginosus seeds. | en_US |
| Affilliation | Universidade Federal de São João Del-Rei. Divinópolis, MG, Brazil | en_US |
| Affilliation | Universidade Federal de São João Del-Rei. Divinópolis, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil | en_US |
| Affilliation | Universidade Federal de São João Del-Rei. Divinópolis, MG, Brazil | en_US |
| Affilliation | Universidade Federal de São João Del-Rei. Divinópolis, MG, Brazil | en_US |
| Subject | Handroanthus | en_US |
| Subject | FAME | en_US |
| Subject | DPPH | en_US |
| Subject | FRAP | en_US |
| Subject | brine shrimp | en_US |
| Embargo date | 2025-12-31 | |
