| Author | Olmo, Roenick P. | |
| Author | Todjro, Yaovi M. H. | |
| Author | Aguiar, Eric R. G. R. | |
| Author | Almeida, João Paulo P. de | |
| Author | Ferreira, Flávia V. | |
| Author | Armache, Juliana N. | |
| Author | Faria, Isaque J. S. de | |
| Author | Ferreira, Alvaro Gil Araujo | |
| Author | Amadou, Siad C. G. | |
| Author | Silva, Ana Teresa S. | |
| Author | Souza, Kátia P. R. de | |
| Author | Vilela, Ana Paula P. | |
| Author | Babarit, Antinea | |
| Author | Tan, Cheong H. | |
| Author | Diallo, Mawlouth | |
| Author | Gaye, Alioune | |
| Author | Paupy, Christophe | |
| Author | Obame-Nkoghe, Judicaël | |
| Author | Visser, Tessa M. | |
| Author | Koenraadt, Constantianus .J M. | |
| Author | Wongsokarijo, Merril A. | |
| Author | Cruz, Ana Luiza C. | |
| Author | Prieto, Mariliza T. | |
| Author | Parra, Maisa C. P. | |
| Author | Nogueira, Maurício L. | |
| Author | Avelino-Silva, Vivian | |
| Author | Mota, Renato N. | |
| Author | Borges, Magno A. Z. | |
| Author | Drumond, Betânia P. | |
| Author | Kroon, Erna G. | |
| Author | Recker, Mario | |
| Author | Sedda, Luigi | |
| Author | Marois, Eric | |
| Author | Imler, Jean-Luc | |
| Author | Marques, João T. | |
| Access date | 2023-03-16T13:52:37Z | |
| Available date | 2023-03-16T13:52:37Z | |
| Document date | 2023 | |
| Citation | OLMO, Roenick P. et al. Mosquito vector competence for dengue is modulated by insect-specific viruses. Nature Microbiology, v. 8, n. 1, p. 135-149, Jan. 2023. | en_US |
| ISSN | 2058-5276 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57402 | |
| Language | eng | en_US |
| Publisher | Nature Publishing Group | en_US |
| Rights | restricted access | |
| Title | Mosquito vector competence for dengue is modulated by insect-specific viruses | en_US |
| Type | Article | |
| DOI | 10.1038/s41564-022-01289-4 | |
| Abstract | Aedes aegypti and A. albopictus mosquitoes are the main vectors for dengue virus (DENV) and other arboviruses, including Zika virus (ZIKV). Understanding the factors that affect transmission of arboviruses from mosquitoes to humans is a priority because it could inform public health and targeted interventions. Reasoning that interactions among viruses in the vector insect might affect transmission, we analysed the viromes of 815 urban Aedes mosquitoes collected from 12 countries worldwide. Two mosquito-specific viruses, Phasi Charoen-like virus (PCLV) and Humaita Tubiacanga virus (HTV), were the most abundant in A. aegypti worldwide. Spatiotemporal analyses of virus circulation in an endemic urban area revealed a 200% increase in chances of having DENV in wild A. aegypti mosquitoes when both HTV and PCLV were present. Using a mouse model in the laboratory, we showed that the presence of HTV and PCLV increased the ability of mosquitoes to transmit DENV and ZIKV to a vertebrate host. By transcriptomic analysis, we found that in DENV-infected mosquitoes, HTV and PCLV block the downregulation of histone H4, which we identify as an important proviral host factor in vivo. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brazil / Université de Strasbourg. Strasbourg, France. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brazil / Department of Biological Sciences. Center of Biotechnology and Genetics. State University of Santa Cruz. Ilhéus, BA, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Université de Strasbourg. Strasbourg, France. | en_US |
| Affilliation | Environmental Health Institute. Vector Biology and Control Division. National Environment Agency. Singapore, Singapore. | en_US |
| Affilliation | Pôle de Zoologie Médicale. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | Pôle de Zoologie Médicale. Institut Pasteur de Dakar. Dakar, Senegal. | en_US |
| Affilliation | Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle. Université de Montpellier. Institut de Recherche pour le Développement. Montpellier, France. | en_US |
| Affilliation | Laboratoire de Biologie Moléculaire et Cellulaire. Département de Biologie. Université des Sciences et Techniques de Masuku. Franceville, Gabon / Écologie des Systèmes Vectoriels. Centre Interdisciplinaire de Recherches Médicales de Franceville. Franceville, Gabon. | en_US |
| Affilliation | Laboratory of Entomology. Wageningen University and Research. Wageningen, the Netherlands. | en_US |
| Affilliation | Laboratory of Entomology. Wageningen University and Research. Wageningen, the Netherlands. | en_US |
| Affilliation | Central Laboratory of the Bureau of Public Health. Paramaribo, Suriname. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Prefeitura de Santos. Secretaria Municipal de Saúde. Seção de Controle de Vetores. Santos, SP, Brazil. | en_US |
| Affilliation | Faculdade de Medicina de São José do Rio Preto. Laboratorio de Pesquisa em Virologia. São José do Rio Preto, MG, Brazil. | en_US |
| Affilliation | Faculdade de Medicina de São José do Rio Preto. Laboratorio de Pesquisa em Virologia. São José do Rio Preto, MG, Brazil / Departament of Pathology. University of Texas Medical Branch. Galveston, TX, USA. | en_US |
| Affilliation | Faculdade de Medicina da Universidade de São Paulo. Departamento de Doenças Infecciosas e Parasitárias. Cerqueira Cesar, SP, Brazil. | en_US |
| Affilliation | Health Surveillance. Brumadinho City Hall. Brumadinho, MG, Brazil. | en_US |
| Affilliation | Universidade Estadual de Montes Claros. Center for Biological and Health Sciences. Montes Claros, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Centre for Ecology and Conservation. University of Exeter. Penryn, UK / Institute of Tropical Medicine. Universitätsklinikum Tübingen. Tübingen, Germany. | en_US |
| Affilliation | Lancaster Medical School. Lancaster University. Lancaster, UK. | en_US |
| Affilliation | Université de Strasbourg. Strasbourg, France. | en_US |
| Affilliation | Université de Strasbourg. Strasbourg, France. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil / Université de Strasbourg. Strasbourg, France. | en_US |
| Subject | Aedes aegypti | en_US |
| Subject | A. albopictus | en_US |
| Subject | Dengue virus | en_US |
| Embargo date | 2099-12-31 | |
