| Author | Coelho, Paulo Marcos Zech | |
| Author | Andrade, Zilton de Araújo | |
| Author | Mello, Rômulo Teixeira de | |
| Author | Costa, Guilherme | |
| Author | Dias, Flávia Sílvia Guimarães | |
| Author | Cunha-Melo, José Renan | |
| Access date | 2023-03-16T16:30:25Z | |
| Available date | 2023-03-16T16:30:25Z | |
| Document date | 2008 | |
| Citation | COELHO Paulo Marcos Zech et al. Post-hepatectomy regeneration of the murine liver I. Effect upon Schistosoma mansoni lesions, before and after chemotherapy. Acta Trop., 108, n. 2-3, p. 104-8, 2008. doi: 10.1016/j.actatropica.2008.01.010.v. | en_US |
| ISSN | 0001-706X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57406 | |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | restricted access | |
| Title | Post-hepatectomy regeneration of the murine liver I. Effect upon Schistosoma mansoni lesions, before and after chemotherapy | en_US |
| Type | Article | |
| DOI | 10.1016/j.actatropica.2008.01.010 | |
| Abstract | Hepatic histopathological changes due to Schistosoma mansoni infection in the mouse presented considerable improvement following partial hepatectomy, both during early (acute) and late (chronic) infections, and especially when surgery was preceded by curative chemotherapy. A 60% hepatectomy removed a great deal of a diseased liver that was replaced by a normal-looking tissue in which schistosomal lesions appeared fewer and scattered. After chemotherapy, residual fibrosis left either from cured acute and chronic schistosomal lesions, almost completely disappeared when the regenerated liver was examined a month afterwards. These marked changes, brought about by hepatectomy in experimental hepatic schistosomiasis, illustrate the fact that post-hepatectomy regeneration tends to restore the normal structure of the liver, even in a diseased organ. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas Goncalo Moniz. Salvador, BA, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas Goncalo Moniz. Salvador, BA, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmacia. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Thomas E. Starzl Transplantation Institute. UPMC. Pittsburgh, PA, USA | en_US |
| Affilliation | Universidade Federal de Minas Gerais Faculdade de Medicina. Departamento de Cirurgia. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais Faculdade de Medicina. Departamento de Cirurgia. Belo Horizonte, MG, Brazil | en_US |
| Subject | 60% hepatectomy | en_US |
| Subject | Schistosoma manson | en_US |
| Subject | Hepatic schistosomiasis | en_US |
| Subject | Periovular granulomas | en_US |
| Subject | Hepatic regeneration | en_US |
| Embargo date | 2099-12-31 | |
