Author | Soares, Milena Botelho Pereira | |
Author | Lima, Ricardo Santana de | |
Author | Rocha, Leonardo Lima | |
Author | Takiya, Christina Maeda | |
Author | Pontes-de-Carvalho, Lain Carlos | |
Author | Carvalho, Antonio Carlos Campos de | |
Author | Santos, Ricardo Ribeiro dos | |
Access date | 2012-10-26T20:55:49Z | |
Available date | 2012-10-26T20:55:49Z | |
Document date | 2004 | |
Citation | SOARES, M. B. et al. Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice. American Journal of Pathology, v. 164, n. 2, p. 441-447, Feb. 2004. | pt_BR |
ISSN | 0002-9440 | |
URI | https://www.arca.fiocruz.br/handle/icict/5741 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice. | pt_BR |
Type | Article | pt_BR |
Abstract | A progressive destruction of the myocardium occurs in approximately 30% of Trypanosoma cruzi-infected individuals, causing chronic chagasic cardiomyopathy, a disease so far without effective treatment. Syngeneic bone marrow cell transplantation has been shown to cause repair and improvement of heart function in a number of studies in patients and animal models of ischemic cardiopathy. The effects of bone marrow transplant in a mouse model of chronic chagasic cardiomyopathy, in the presence of the disease causal agent, ie, the T. cruzi, are described herein. Bone marrow cells injected intravenously into chronic chagasic mice migrated to the heart and caused a significant reduction in the inflammatory infiltrates and in the interstitial fibrosis characteristics of chronic chagasic cardiomyopathy. The beneficial effects were observed up to 6 months after bone marrow cell transplantation. A massive apoptosis of myocardial inflammatory cells was observed after the therapy with bone marrow cells. Transplanted bone marrow cells obtained from chagasic mice and from normal mice had similar effects in terms of mediating chagasic heart repair. These results show that bone marrow cell transplantation is effective for treatment of chronic chagasic myocarditis and indicate that autologous bone marrow transplant may be used as an efficient therapy for patients with chronic chagasic cardiomyopathy. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Institutos de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
DeCS | Transplante de Medula Óssea | pt_BR |
DeCS | Cardiomiopatia Chagásica/cirurgia | pt_BR |
DeCS | Miocárdio/patologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Apoptose/fisiologia | pt_BR |
DeCS | Movimento Celular | pt_BR |
DeCS | Cardiomiopatia Chagásica/etiologia | pt_BR |
DeCS | Doença Crônica | pt_BR |
DeCS | Modelos Animais de Doenças | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Fibrose/patologia | pt_BR |
DeCS | Marcação In Situ das Extremidades Cortadas | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Trypanosoma cruzi | pt_BR |