| Author | Srinivas, Tara | |
| Author | Mathias, Carolina | |
| Author | Oliveira-Mateos, Cristina | |
| Author | Guil, Sonia | |
| Access date | 2023-03-21T15:11:40Z | |
| Available date | 2023-03-21T15:11:40Z | |
| Document date | 2023 | |
| Citation | SRINIVAS, Tara et al. Roles of lncRNAs in brain development and pathogenesis: Emerging therapeutic opportunities. Molecular Therapy, v. 31, n. 4, p. 1–12, 2023. | en_US |
| ISSN | 1525-0024 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57480 | |
| Language | por | en_US |
| Publisher | Cell Press | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | lncRNAs | en_US |
| Subject in Portuguese | Doenças Cerebrais | en_US |
| Title | Roles of lncRNAs in brain development and pathogenesis: Emerging therapeutic opportunities | en_US |
| Type | Article | en_US |
| DOI | https://doi.org/10.1016/j.ymthe.2023.02.008 | |
| Abstract | The human genome is pervasively transcribed, producing a majority of short and long noncoding RNAs (lncRNAs) that can influence cellular programs through a variety of transcriptional and post-transcriptional regulatory mechanisms. The brain houses the richest repertoire of long noncoding transcripts, which function at every stage during central nervous system development and homeostasis. An example of functionally relevant lncRNAs is species involved in spatiotemporal organization of gene expression in different brain regions, which play roles at the nuclear level and in transport, translation, and decay of other transcripts in specific neuronal sites. Research in the field has enabled identification of the contributions of specific lncRNAs to certain brain diseases, including Alzheimer’s disease, Parkinson’s disease, cancer, and neurodevelopmental disorders, resulting in notions of potential therapeutic strategies that
target these RNAs to recover the normal phenotype. Here, we summarize the latest mechanistic findings associated with lncRNAs in the brain, focusing on their dysregulation in neurodevelopmental or neurodegenerative disorders, their use as biomarkers for central nervous system (CNS) diseases in vitro and in vivo, and their potential utility for therapeutic strategies. | en_US |
| Affilliation | Josep Carreras Leukaemia Research Institute. Barcelona, Catalonia, Spain. | en_US |
| Affilliation | Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | en_US |
| Affilliation | Josep Carreras Leukaemia Research Institute. Barcelona, Catalonia, Spain. | en_US |
| Affilliation | Josep Carreras Leukaemia Research Institute. Barcelona, Catalonia, Spain. / Germans Trias i Pujol Health Science Research Institute. Barcelona, Catalonia, Spain. | en_US |
| Subject | RNA, Long Noncoding | en_US |
| Subject | Brain Diseases | en_US |
| Subject | Therapeutics | en_US |
| Subject in Spanish | ARN Largo no Codificante | en_US |
| Subject in Spanish | Encefalopatías | en_US |
| Subject in Spanish | Terapéutica | en_US |
| Subject in French | ARN long non codant | en_US |
| Subject in French | Encéphalopathies | en_US |
| Subject in French | Thérapeutique | en_US |
| DeCS | RNA Longo não Codificante | en_US |
| DeCS | Encefalopatias | en_US |
| DeCS | Terapêutica | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
