| Author | Silveira, Alexandre Barcelos Morais da | |
| Author | Reis, D. D’Avila | |
| Author | Oliveira, Elaine Cristina de | |
| Author | Gabriel Neto, Salustiano | |
| Author | Ostermayer, Alejandro Luquetti | |
| Author | Poole, D. | |
| Author | Oliveira, Rodrigo Corrêa de | |
| Author | Furness, J. B. | |
| Access date | 2023-03-24T13:28:26Z | |
| Available date | 2023-03-24T13:28:26Z | |
| Document date | 2007 | |
| Citation | SILVEIRA, Alexandre Barcelos Morais da et al. Neurochemical coding of the enteric nervous system in chagasic patients with megacolon. Dig Dis Sci., v. 52, n. 10, 2877-2883, 2007. doi: 10.1007/s10620-006-9680-5. | en_US |
| ISSN | 1573-2568 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57553 | |
| Language | eng | en_US |
| Publisher | Springer Science | en_US |
| Rights | restricted access | |
| Title | Neurochemical coding of the enteric nervous system in chagasic patients with megacolon | en_US |
| Type | Article | |
| DOI | 10.1007/s10620-006-9680-5 | |
| Abstract | Neuronal destruction has been considered the hallmark of pathogenic mechanisms in chagasic megacolon. Characterization of neuropeptides in the enteric nervous system from chagasic patients with megacolon could elucidate some aspects of the development of this syndrome. In the present work we demonstrate the changes in expression of neuropeptides and neurochemical markers present in neuronal plexuses from the colons of chagasic patients with megacolon. Sections of frozen tissue samples were immunohistochemically labeled for anticalretinin, cChaT, substance P, VIP, NOS, and NPY. Immunoreactivity was observed using a confocal microscope. Our results demonstrate that in chagasic patients with megacolon, inhibitory motor neurons ( VIP and NOS immunoreactive) are preferentially destroyed by Trypanosoma cruzi and/or the inflammatory process. These results suggest a selective destruction of enteric neurons in the colon of chagasic patients with megacolon, pointing to an important discovery in the mechanism of pathogenesis of Chagas' disease | en_US |
| Affilliation | Department of Morphology. Instituto de Ciencias Biologicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil | en_US |
| Affilliation | Department of Morphology. Instituto de Ciencias Biologicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil | en_US |
| Affilliation | Department of Surgery. Medical School. Universidade Federal de Goiass. Goias. GO, Brazil | en_US |
| Affilliation | Department of Surgery. Medical School. Universidade Federal de Goiass. Goias. GO, Brazil | en_US |
| Affilliation | Chagas’ Disease Research Laboratory. IPTSP. Universidade Federal de Goias. Goias. GO, Brazil | en_US |
| Affilliation | Department of Anatomy & Cell Biology and Centre for Neuroscience. University of Melbourne. Victoria, Australia | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Department of Anatomy & Cell Biology and Centre for Neuroscience. University of Melbourne. Victoria, Australia | en_US |
| Subject | Chagas' disease | en_US |
| Subject | chagasic megacolon | en_US |
| Subject | enteric nervous system | en_US |
| Subject | neurochemical markers | en_US |
| Subject | neuropeptides | en_US |
| Embargo date | 2099-12-31 | |
