| Author | Costa, Maria Fernanda Furtado Lima | |
| Author | Costa, Erico de Castro | |
| Author | Demicheli, Maria Elizabeth Uchôa de Oliveira | |
| Author | Firmo, Josélia Oliveira Araújo | |
| Author | Ribeiro, Antonio Luiz P. | |
| Author | Ferri, Cleusa P. | |
| Author | Prince, Martin | |
| Access date | 2023-03-24T13:35:10Z | |
| Available date | 2023-03-24T13:35:10Z | |
| Document date | 2009 | |
| Citation | COSTA, Maria Fernanda Furtado Lima et al. A population-based study of the association between Trypanosoma cruzi infection and cognitive impairment in old age (the Bambuí Study). Comparative Study Neuroepidemiology, v. 32, n. 2, p. 122-128, 2009. doi: 10.1159/000182819. | en_US |
| ISSN | 0251-5350 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57555 | |
| Language | eng | en_US |
| Publisher | Karger | en_US |
| Rights | restricted access | |
| Title | A Population-Based Study of the Association between Trypanosoma cruzi Infection and Cognitive Impairment in Old Age (The Bambui Study) | en_US |
| Type | Article | |
| DOI | 10.1159/000182819 | |
| Abstract | Background: Limited clinical data suggest that chronic Trypanosoma cruzi infection, which causes Chagas' disease (ChD), is associated with cognitive impairment. This study investigated this association in a large population-based sample of older adults. Methods: Participants in this cross-sectional study comprised 1,449 persons aged 6 60 years from a Brazilian endemic area (Bambu). Cognitive functioning was ascertained by the Mini-Mental State Examination (MMSE), considering its score in percentiles [<= 14 (<5th percentile), 15-22 (5th to <25th) and 6 23]. Hypothesized risk factors were T. cruzi infection, ChD-related electrocardiographic (ECG) abnormalities and use of digoxin medication. Potential confounders included depressive symptoms, smoking, stroke, hemoglobin, HDL cholesterol, blood glucose, systolic blood pressure, and use of psychoactive medication. Results: The prevalence of T. cruzi infection was 37.6%. There was a graded and independent association between infection and the MMSE score (adjusted odds ratios estimated by ordinal logistic regression = 1.99; 95% CI 1.43-2.76). No significant associations between the MMSE score and ECG abnormalities or digoxin medication use were found. Conclusions: This study provides for the first time epidemiological evidence of an association between T. cruzi infection and cognitive impairment which was not mediated by either ChD-related ECG abnormalities or digoxin medication use. Copyright (C) 2008 S. Karger AG, Basel | en_US |
| Affilliation | Public Health and Ageing Research Group. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brasil | en_US |
| Affilliation | Public Health and Ageing Research Group. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brasil/Health Service and Population Research Department. Institute of Psychiatry. King’s College London. London, UK | en_US |
| Affilliation | Public Health and Ageing Research Group. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brasil/Federal University of Minas Gerais. Medical School. Belo Horizonte MG, Brazil | en_US |
| Affilliation | Public Health and Ageing Research Group. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brasil/Federal University of Minas Gerais. Medical School. Belo Horizonte MG, Brazil | en_US |
| Affilliation | Federal University of Minas Gerais. Medical School. Belo Horizonte MG, Brazil | en_US |
| Affilliation | Health Service and Population Research Department. Institute of Psychiatry. King’s College London. London, UK | en_US |
| Affilliation | Health Service and Population Research Department. Institute of Psychiatry. King’s College London. London, UK | en_US |
| Subject | Cognitive impairment | en_US |
| Subject | Trypanosoma cruzi infection | en_US |
| Subject | Chagas' disease | en_US |
| Subject | Elderly | en_US |
| Subject | Elderly | en_US |
