| Author | Pescarini, Julia M. | |
| Author | Cardoso, Andrey Moreira | |
| Author | Santos, Ricardo Ventura | |
| Author | Scaff, Priscila | |
| Author | Paixao, Enny S. | |
| Author | Ranzani, Otavio T. | |
| Author | Silva, Thiago Cerqueira | |
| Author | Boaventura, Viviane S. | |
| Author | Bertoldo Junior, Juracy | |
| Author | Oliveira, Vinicius de A. | |
| Author | Werneck, Guilherme L. | |
| Author | Barreto, Mauricio L. | |
| Author | Barral Netto, Manoel | |
| Access date | 2023-03-27T14:08:27Z | |
| Available date | 2023-03-27T14:08:27Z | |
| Document date | 2022 | |
| Citation | PESCARINI, Julia M. et al. Vaccine coverage and effectiveness against laboratory-confirmed symptomatic and severe Covid-19 in indigenous people in Brazil: a cohort study. The Lancet, p. 1-19, 2022. | |
| ISSN | 0140-6736 | |
| URI | https://www.arca.fiocruz.br/handle/icict/57588 | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | open access | |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | Pandemia | pt_BR |
| Subject in Portuguese | Eficácia da vacina | pt_BR |
| Subject in Portuguese | Cobertura vacinal | pt_BR |
| Subject in Portuguese | Estudo de coorte | pt_BR |
| Subject in Portuguese | Pessoas indígenas | pt_BR |
| Subject in Portuguese | Serviços de saúde | pt_BR |
| Subject in Portuguese | População indígena | pt_BR |
| Subject in Portuguese | Saúde dos indígenas | pt_BR |
| Subject in Portuguese | Ameríndios | pt_BR |
| Subject in Portuguese | índios | pt_BR |
| Subject in Portuguese | Sul Americano | pt_BR |
| Subject in Portuguese | Grupos vulneráveis | pt_BR |
| Subject in Portuguese | Transmissão de doenças infecciosas | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Vaccine coverage and effectiveness against laboratory-confirmed symptomatic and severe Covid-19 in indigenous people in Brazil: a cohort study | en_US |
| Type | Preprint | |
| DOI | 10.2139/ssrn.4224510 | |
| Abstract | Background: We estimated the coverage and effectiveness of Covid-19 vaccines against laboratory-confirmed Covid-19 cases among indigenous people in Brazil. Methods: We linked nationwide immunization data with symptomatic and Severe Acute Respiratory Infection records and studied a cohort of vaccinated indigenous people aged ≥5 years between 18th Jan 2021 and 1st Mar 2022. We estimated the Covid-19 vaccination coverage and used Poisson regression to calculate the vaccine effectiveness (VE) of CoronaVac, ChAdOx1, and BNT162b2 against Covid-19 laboratory-confirmed symptomatic and severe cases (i.e., mortality, hospitalisation, and hospital-progression to Intensive Care Unit (ICU) or death). VE was estimated as (1-RR)*100, comparing unexposed (<14 days after the 1st dose), to partially (≥14 days after 1st dose to <14 days after 2nd dose), or fully vaccinated (≥14 days after 2nd dose). Findings: By 1st Mar 2022, 48·7% (35·0-62·3) of eligible indigenous people vs 74·8% (57·9-91·8) overall Brazilians had been fully vaccinated for Covid-19. Among the 370,092 indigenous subjects studied, we detected 1951 Covid-19 cases, of which 105 were hospitalised and 35 died. VE for the three Covid-19 vaccines combined was 53% (95%CI:44-60%) for symptomatic cases, 53% (95%CI:-56-86%) for mortality and 41% (95%CI:-35-75%) for hospitalisation. Among hospitalised patients, VE was 87% (95%CI:27-98%) for progression to ICU and 96% (95%CI: 90-99%) for death. Interpretation: Lower coverage but similar Covid-19 vaccine effectiveness among indigenous people than overall Brazilians suggest the need to expand access, timely vaccination, especially among children and adolescents, and urgently offer booster doses to achieve a great level of protection among this group. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / London School of Hygiene and Tropical Medicine. London, United Kingdom. | |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Museu Nacional. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / London School of Hygiene and Tropical Medicine. London, United Kingdom. | |
| Affilliation | Barcelona Institute for Global Health. ISGlobal. Universitat Pompeu Fabra (UPF). CIBER Epidemiología y Salud Pública (CIBERESP). Barcelona, Spain / Universidade de São Paulo. Faculdade de Medicina. Instituto do Coração. Hospital das Clínicas. Divisão Pulmonar. São Paulo, SP, Brasil. | |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratórios LIB e LEITV. Salvador, BA, Brasil. | |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratórios LIB e LEITV. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Barcelona Institute for Global Health. ISGlobal. Universitat Pompeu Fabra (UPF). CIBER Epidemiología y Salud Pública (CIBERESP). Barcelona, Spain / Universidade Federal da Bahia. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratórios LIB e LEITV. Salvador, BA, Brasil. | |
| Affilliation | Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Laboratórios LIB e LEITV. Salvador, BA, Brasil. | |
| Subject | COVID-19 | en_US |
| Subject | Pandemic | en_US |
| Subject | Vaccine effectiveness | en_US |
| Subject | Vaccine coverage | en_US |
| Subject | Cohort study | en_US |
| Subject | Indigenous peoples | en_US |
| Subject | Health services | en_US |
| Subject | Indigenous population | en_US |
| Subject | Health of indigenous people | en_US |
| Subject | Amerinds | en_US |
| Subject | Indians | en_US |
| Subject | South American | en_US |
| Subject | Vulnerable groups | en_US |
| Subject | Infectious disease transmission | en_US |
| Subject | Brazil | en_US |
| xmlui.metadata.dc.subject.ods | 01 Erradicação da pobreza | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 16 Paz, Justiça e Instituições Eficazes | |
