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AutorLeonhard SE
AutorHalstead S
AutorLant SB
AutorMilitão de Albuquerque MFP
Autorde Brito CAA
Autorde Albuquerque LBB
AutorEllul MA
Autorde Oliveira França RF
AutorGourlay D
AutorGriffiths MJ
Autorde Miranda Henriques-Souza AM
Autorde Morais Machado MÍ
AutorMedialdea-Carrera R
AutorMehta R
Autorda Paz Melo R
AutorMesquita SD
AutorMoreira ÁJP
AutorPena LJ
AutorSantos ML
AutorTurtle L
AutorSolomon T
AutorWillison HJ
AutorJacobs BC
AutorBrito Ferreira ML.
Fecha de acceso2023-04-05T14:41:50Z
Fecha de disponibilización2023-04-05T14:41:50Z
Fecha de publicación2021
ReferenciaLeonhard SE, Halstead S, Lant SB, Militão de Albuquerque MFP, de Brito CAA, de Albuquerque LBB, Ellul MA, de Oliveira França RF, Gourlay D, Griffiths MJ, de Miranda Henriques-Souza AM, de Morais Machado MÍ, Medialdea-Carrera R, Mehta R, da Paz Melo R, Mesquita SD, Moreira ÁJP, Pena LJ, Santos ML, Turtle L, Solomon T, Willison HJ, Jacobs BC, Brito Ferreira ML. Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study. J Neurol Sci. 2021 Jan 15;420:117272. doi: 10.1016/j.jns.2020.117272. Epub 2020 Dec 14. PMID: 33360425.en_US
ISSN1878-5883en_US
URIhttps://www.arca.fiocruz.br/handle/icict/57693
Idiomaengen_US
Derechos de autoropen accessen_US
TítuloGuillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort studyen_US
Tipo del documentoArticleen_US
DOI10.1016/j.jns.2020.117272
Resumen en InglésObjective: To determine the clinical phenotype of Guillain-Barré syndrome (GBS) after Zika virus (ZIKV) infection, the anti-glycolipid antibody signature, and the role of other circulating arthropod-borne viruses, we describe a cohort of GBS patients identified during ZIKV and chikungunya virus (CHIKV) outbreaks in Northeast Brazil. Methods: We prospectively recruited GBS patients from a regional neurology center in Northeast Brazil between December 2014 and February 2017. Serum and CSF were tested for ZIKV, CHIKV, and dengue virus (DENV), by RT-PCR and antibodies, and serum was tested for GBS-associated antibodies to glycolipids. Results: Seventy-one patients were identified. Forty-eight (68%) had laboratory evidence of a recent arbovirus infection; 25 (52%) ZIKV, 8 (17%) CHIKV, 1 (2%) DENV, and 14 (29%) ZIKV and CHIKV. Most patients with a recent arbovirus infection had motor and sensory symptoms (72%), a demyelinating electrophysiological subtype (67%) and a facial palsy (58%). Patients with a recent infection with ZIKV and CHIKV had a longer hospital admission and more frequent mechanical ventilation compared to the other patients. No specific anti-glycolipid antibody signature was identified in association with arbovirus infection, although significant antibody titres to GM1, GalC, LM1, and GalNAc-GD1a were found infrequently. Conclusion: A large proportion of cases had laboratory evidence of a recent infection with ZIKV or CHIKV, and recent infection with both viruses was found in almost one third of patients. Most patients with a recent arbovirus infection had a sensorimotor, demyelinating GBS. We did not find a specific anti-glycolipid antibody signature in association with arbovirus-related GBS.en_US
AfiliaciónUniversity of Glasgow, Department of Neurology and Institute of Infection, Immunity and Inflammation, Glasgow, UK. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Saúde Coletiva, Recife, Pernambuco, Brasil. Universidade Federal de Pernambuco, Departamento de Medicina Clinica , Recife, Brazil. Instituto de Medicina Integral Professor Fernando Figueira (IMIP) Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; The Walton Centre NHS Foundation Trust, Liverpool, UK. Fundação Oswaldo Cruz, Instituto Aggeu Magalhães,Departamento de Virologia, Recife, Brasil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Alder Hey Children's NHS Foundation Trust, Liverpool, UK. Hospital da Restauração, Departamento de Pediatria Neurologica, Recife, Brasil. Hospital da Restauração, Departamento de Neurologia Recife, Brazil. National Institute for Health Research Health Protection Research Unit on Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK. Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.
Palavras clave en InglêsGuillain-Barr ́e syndromeen_US
Palavras clave en InglêsZika virusen_US
Palavras clave en InglêsChikungunya virusen_US
Palavras clave en InglêsArbovirusen_US
Palavras clave en InglêsNeuroinflammatory diseaseen_US


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