| Author | Cambou, Mary C. | |
| Author | Liu, Christine M. | |
| Author | Mok, Thalia | |
| Author | Fajardo-Martinez, Viviana | |
| Author | Paiola, Sophia G. | |
| Author | Ibarrondo, Francisco J. | |
| Author | Kerin, Tara | |
| Author | Fuller, Trevon | |
| Author | Tobin, Nicole H. | |
| Author | Garcia, Gustavo | |
| Author | Bhattacharya, Debika | |
| Author | Aldrovandi, Grace M. | |
| Author | Arumugaswami, Vaithilingaraja | |
| Author | Suan-Sin, Foo | |
| Author | Jung, Jae U. | |
| Author | Vasconcelos, Zilton | |
| Author | Brasil, Patricia | |
| Author | Brendolin, Michelle | |
| Author | Yang, Otto | |
| Author | Rao, Rashmi | |
| Author | Nielsen-Saines, Karin | |
| Access date | 2023-04-14T23:08:57Z | |
| Available date | 2023-04-14T23:08:57Z | |
| Document date | 2022 | |
| Citation | CAMBOU, Mary C. et al. Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads After Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy. The Journal of Infectious Diseases, v. 227, n. 2, p. 236-245, Jan 11, 2023. | |
| ISSN | 0022-1899 | |
| URI | https://www.arca.fiocruz.br/handle/icict/57798 | |
| Language | eng | en_US |
| Rights | open access | |
| Subject in Portuguese | COVID-19 | pt_BR |
| Subject in Portuguese | SARS-CoV-2 | pt_BR |
| Subject in Portuguese | Transferência transplacentária | pt_BR |
| Title | Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancy | en_US |
| Type | Preprint | |
| DOI | 10.1093/infdis/jiac366 | |
| Abstract | Background: There are limited data on how coronavirus disease 2019 (COVID-19) severity, timing of infection, and subsequent vaccination impact transplacental transfer and persistence of maternal and infant antibodies. Methods: In a longitudinal cohort of pregnant women with polymerase chain reaction-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, maternal/infant sera were collected at enrollment, delivery/birth, and 6 months. Anti-SARS-CoV-2 spike immunoglobulin (Ig)G, IgM, and IgA were measured by enzyme-linked immunosorbent assay. Results: Two-hundred fifty-six pregnant women and 135 infants were enrolled; 148 maternal and 122 neonatal specimens were collected at delivery/birth; 45 maternal and 48 infant specimens were collected at 6 months. Sixty-eight percent of women produced all anti-SARS-CoV-2 isotypes at delivery (IgG, IgM, IgA); 96% had at least 1 isotype. Symptomatic disease and vaccination before delivery were associated with higher maternal IgG at labor and delivery. Detectable IgG in infants dropped from 78% at birth to 52% at 6 months. In the multivariate analysis evaluating factors associated with detectable IgG in infants at delivery, significant predictors were 3rd trimester infection (odds ratio [OR] = 4.0), mild/moderate disease (OR = 4.8), severe/critical disease (OR = 6.3), and maternal vaccination before delivery (OR = 18.8). No factors were significant in the multivariate analysis at 6 months postpartum. Conclusions: Vaccination in pregnancy post-COVID-19 recovery is a strategy for boosting antibodies in mother-infant dyads. | en_US |
| Affilliation | University of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA. | |
| Affilliation | University of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA. | |
| Affilliation | University of California. Department of Obstetrics and Gynecology. David Geffen School of Medicine. Los Angeles, California, USA. | |
| Affilliation | University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA. | |
| Affilliation | University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA. | |
| Affilliation | University of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA. | |
| Affilliation | University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA. | |
| Affilliation | University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA. | |
| Affilliation | University of California. Department of Molecular and Medical Pharmacology. Los Angeles, California, USA. | |
| Affilliation | University of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA. | |
| Affilliation | University of California. Department of Obstetrics and Gynecology. David Geffen School of Medicine. Los Angeles, California, USA. | |
| Affilliation | University of California. Department of Molecular and Medical Pharmacology. Los Angeles, California, USA. | |
| Affilliation | Department of Cancer Biology. Infection Biology Program and Global Center for Pathogen and Human Health Research Cleveland Clinic. Cleveland, Ohio, USA. | |
| Affilliation | Department of Cancer Biology. Infection Biology Program and Global Center for Pathogen and Human Health Research Cleveland Clinic. Cleveland, Ohio, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Maternidade do Hospital Estadual Adão Pereira Nunes. Caxias, RJ, Brazil. | |
| Affilliation | University of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA. | |
| Affilliation | University of California. Department of Obstetrics and Gynecology. David Geffen School of Medicine. Los Angeles, California, USA. | |
| Affilliation | University of California. Department of Obstetrics and Gynecology. David Geffen School of Medicine. Los Angeles, California, USA. | |
| Affilliation | University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA. | |
| Subject | COVID-19 | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | Transplacental transfer | en_US |
