| Author | Silva, Marcos Antonio Custódio Neto da | |
| Author | Wolff, Laís Araújo Souza | |
| Author | Borges, Kátia Regina Assunção | |
| Author | Vale, André Alvares Marques | |
| Author | Azevedo-Santos, Ana Paula Silva de | |
| Author | Xavier, Marcelo Antônio Pascoal | |
| Author | Barbosa, Maria do Carmo Lacerda | |
| Author | Nascimento, Maria do Desterro Soares Brandão | |
| Author | Carvalho, João Ernesto de | |
| Access date | 2023-04-24T13:17:22Z | |
| Available date | 2023-04-24T13:17:22Z | |
| Document date | 2023 | |
| Citation | SILVA, Marcos Antonio Custódio Neto da et al. Açaí (Euterpe oleracea Mart.) byproduct reduces tumor size and modulates inflammation in Ehrlich mice model. Journal of Functional Foods, v. 103, 105474, 2023. doi.org/10.1016/j.jff.2023.105474 | en_US |
| ISSN | 1756-4646 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/57926 | |
| Language | eng | en_US |
| Publisher | Elsevier Ltd. | en_US |
| Rights | restricted access | |
| Title | Açaí (Euterpe oleracea Mart.) byproduct reduces tumor size and modulates inflammation in Ehrlich mice model | en_US |
| Type | Article | |
| Abstract | Açaí, Euterpe oleracea Mart. is rich in several phytochemical substances with antioxidant, anti-inflammatory and antitumor activities. The açaí seed is a waste product, being little used in the economy, being relevant to study the antitumor properties of this by-product. This study aims to analyze the effects of hydroalcoholic açaí seed extract in Ehrlich mice model in preventive and treatment schemes. The animals were treated with different concentrations of the extract (100, 300 and 1000 mg/kg) by gavage in preventive (30 days before tumor induction) and intervention (15 days after tumor induction) regimens. In in vivo experiments, the use of the extract at a dose of 1000 mg/kg in preventive regimens reduced tumor volume, decreased tumor weight, maintained the weight of treated animals and induced an immunomodulatory response, with an increase in TNF-α. The treatment also increased the area of tumor necrosis when compared to the control. Our results suggest the antitumor potential of açaí seed extract in in vivo models of breast cancer, contributing to obtain an active drug from a known natural product. In addition, the use of açaí seed residue will contribute to the local economy and sustainability. | en_US |
| Affilliation | Faculty of Medical Science. Post-graduate Program in Internal Medicine. Universidade Estadual de Campinas. Campinas, SP, Brazil/Medicine Course. Federal University of Maranhão. Imperatriz, MA, Brazil | en_US |
| Affilliation | Federal University of Maranhão. Post-graduate Program in Adult Heath. Department of Patology. São Luís, MA, Brazil | en_US |
| Affilliation | Federal University of Maranhão. Post-graduate Program in Adult Heath. Department of Patology. São Luís, MA, Brazil | en_US |
| Affilliation | Laboratory of Applied Cancer Immunology. Biological and Health Sciences Center. Federal University of Maranhão. São Luis, MA, Brazil/Post-graduate Program in Health Sciences. São Luís, MA, Brazil | en_US |
| Affilliation | Laboratory of Applied Cancer Immunology. Biological and Health Sciences Center. Federal University of Maranhão. São Luis, MA, Brazil/Post-graduate Program in Health Sciences. São Luís, MA, Brazil | en_US |
| Affilliation | Federal University of Minas Gerais. Department of Pathological Anatomy and Forensic Medicine. Belo Horizonte, MG, Brazil/ René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Federal University of Maranhão. Post-graduate Program in Family Health. Department of Medicine I. São Luís, MA, Brazil | en_US |
| Affilliation | Federal University of Maranhão. Post-graduate Program in Adult Heath. Department of Patology. São Luís, MA, Brazil | en_US |
| Affilliation | Faculty of Pharmaceutical Sciences. State University of Campinas. Campinas, SP, Brazil | en_US |
| Embargo date | 2030-12-31 | |
