| Author | Cançado, Guilherme Grossi Lopes | |
| Author | Fujiwara, Ricardo Toshio | |
| Author | Freitas, Paulo Roberto de | |
| Author | Oliveira, Rodrigo Corrêa | |
| Author | Bethony, Jeffrey Michael | |
| Access date | 2023-05-12T13:53:32Z | |
| Available date | 2023-05-12T13:53:32Z | |
| Document date | 2009 | |
| Citation | CANÇADO, Guilherme Grossi Lopes et al. Acute generalized exanthematous pustulosis induced by itraconazole: an immunological approach. Clinical and Experimental Dermatology, v. 34, n. 8, p. e709–e711, 2009. .org/10.1111/j.1365-2230.2009.03440.x | en_US |
| ISSN | 0307-6938 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/58347 | |
| Language | eng | en_US |
| Publisher | British College of Dermatology | en_US |
| Rights | restricted access | |
| Title | Acute generalized exanthematous pustulosis induced by itraconazole: an immunological approach | en_US |
| Type | Article | |
| DOI | 10.1111/j.1365-2230.2009.03440.x | |
| Abstract | Acute generalized exanthematous pustulosis (AGEP) is an uncommon disease, which presents as a nonfollicular erythematous sterile pustular eruption. More than 90% of the cases are induced by adverse drug reactions, often triggered by anti-infectious systemic drugs. We report a case of itraconazole-induced AGEP in a 22-year-old man, with an assessment of his cytokine/chemokine production and drug-specific cell reactivity. We found that AGEP, like other T cell-mediated drug eruptions, alters the immunological status of the patient, probably favouring T-cell activation, recruitment and regulation. Few cases of itraconazole-induced AGEP have been described in the literature, and to our knowledge, this is the first report in which the cellular immunological features are assessed | en_US |
| Affilliation | Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Clinical Immunology Laboratory. George Washington University. Washington, DC, USA | en_US |
