| Author | Frota, Lêda Maria da Costa Pinheiro | |
| Author | Sampaio, Rosana Ferreira | |
| Author | Miranda, José Lucivan | |
| Author | Brasil, Rita Maria Cavalcante | |
| Author | Gontijo, Ana Paula Bensemann | |
| Author | Mambrini, Juliana Vaz de Melo | |
| Author | Brandão, Marina de Brito | |
| Author | Mancini, Marisa Cotta | |
| Access date | 2023-05-15T17:02:38Z | |
| Available date | 2023-05-15T17:02:38Z | |
| Document date | 2020 | |
| Citation | FROTA, Lêda Maria da Costa Pinheiro et al. Children with congenital Zika syndrome: symptoms, comorbidities and gross motor development at 24 months of age. Heliyon, v. 6, n. 6, e04130, 2020. doi: 10.1016/j.heliyon.2020.e04130 | en_US |
| ISSN | 2405-8440 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/58396 | |
| Language | eng | en_US |
| Publisher | Elsevier Ltd | en_US |
| Rights | restricted access | en_US |
| Title | Children with congenital Zika syndrome: symptoms, comorbidities and gross motor development at 24 months of age | en_US |
| Type | Article | en_US |
| DOI | 10.1016/j.heliyon.2020.e04130 | |
| Abstract | Background: Children with congenital Zika syndrome (CZS) maintain severe motor impairments at the end of the first year of life. Presence of certain symptoms and comorbidities increase these children's vulnerability.
Aims: To evaluate gross motor function of a group of Brazilian children with CZS at 24 months of age and to investigate the association between the presence of CZS symptoms and comorbidities with gross motor development.
Methods and procedures: Fifty children with CZS participated in the study. Information was collected from medical charts, and gross motor development was evaluated by the Gross Motor Function Measure (GMFM)-88. GMFM-88 scores were compared among comorbid groups. Three subgroups of children were identified by cluster analysis, based on information from head circumference at birth, symptoms, comorbidities and gross motor function.
Outcomes and results: Significant associations (p < 0.001) were observed between number of comorbidities/symptoms and dimensions A (r = -0.57) and B (r = -0.58) of the GMFM-88. Children were grouped into 3 clusters, with different gross motor skills. Children with epilepsy and dysphagia composed the cluster with smaller median scores for dimensions A and B of the GMFM-88.
Conclusions and implications: The presence of CZS symptoms and comorbidities compromise the gross motor repertoire of children with CZS at 24 months. | en_US |
| Affilliation | Interinstitutional Doctorate Program. Graduate Program in Rehabilitation Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/Center for Treatment and Early Stimulation. Fortaleza, CE, Brazil | en_US |
| Affilliation | Department of Physical Therapy. Graduate Program in Rehabilitation Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Department of Maternal and Child Health. Universidade Federal do Ceará. Fortaleza, CE, Brazil/Center for Treatment and Early Stimulation. Fortaleza, CE, Brazil | en_US |
| Affilliation | Center for Treatment and Early Stimulation. Fortaleza, CE, Brazil | en_US |
| Affilliation | Department of Physical Therapy. School of Physical Education. Physical Therapy and Occupational Therapy. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Department of Occupational Therapy. Graduate Program in Rehabilitation Sciences. School of Physical Education. Physical Therapy and Occupational Therapy. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Neuroscience, Virology, Disability, Musculoskeletal system, Nervous system, Pediatrics, Health promotion, Zika virus, Microcephaly, Dysphagia, Epilepsy, Motor skills | en_US |
| Subject | Neuroscience | en_US |
| Subject | Virology | en_US |
| Subject | Disability | en_US |
| Subject | Musculoskeletal system | en_US |
| Subject | Nervous system | en_US |
| Subject | Pediatrics | en_US |
| Subject | Health promotion | en_US |
| Subject | Zika virus | en_US |
| Subject | Microcephaly | en_US |
| Subject | Dysphagia | en_US |
| Subject | Epilepsy | en_US |
| Subject | Motor skills | en_US |
| Embargo date | 2099-12-31 | |
